000			a
999			_c15554 _d15554
003			OSt
005			20211123104232.0
008			211123b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_914750 _aBasu, Ananya
245			_aDesign and Characterization of Sustained Release in situ Gastric Floating Gel of Ropinirole Hydrochloride
250			_aVol.55(2), Apr-Jun
260			_aBanaglore _bAssociation of Pharmaceutical Teachers of India (APTI) _c2021
300			_a374-382p.
520			_aBackground: This in situ solution which on gelation floats in the gastric region is suitable for sustaining the release of the drug. In the present research work, Ropinirole Hydrochloride which is an Anti-parkinson agent, used to formulate an in situ gel for prolonged action. Materials and Methods: Sodium alginate is a natural polymer used to form the gel matrix, calcium carbonate plays a dual role i.e. the source of CO2 entrapped in the matrix for floatation of gel and source of Ca2+ ion for sol to gel transition, HPMC K100M as the release retard polymer was investigated. The mechanism for the floatation of the gel was pH induced ion gelation. For the formulated in situ solution different evaluation parameters were used. Results and Discussion: On the basis of the outcomes pale colored, viscous solution of uniform consistency was obtained, the drug content was found to be >87%, the viscosities were in the acceptable range suitable for swallowing, pH was found to be in the range of 7.35-7.87 which was compatible for oral ingestion. Design Expert 12 software was used to derive the results of interaction and responses on the basis of concentration of polymer and statistical analysis. F5 (0.75mg SA and 0.5mg HPMC) the optimized formulation showed a slow drug release of 96.10% up to 12 h. The best fit model for the drug release was Korsmeyer Peppas model which explained drug release on imbibition of water from surrounding by polymer matrix. Conclusion: The in situ gel prepared can ultimately provide prolonged release, enhance the bioavailability of the drug and increase the patient compliance due to development of a once in a day dosage form in comparison to multi dose of tablets therefore, can be considered as promising dosage form for increased therapeutic action.
650		0	_94639 _aPHARMACEUTICS
700			_914751 _a Masareddy, Rajashree Shashidhar
773	0		_tIndian journal of pharmaceutical education and research _dBengluru Association of Pharmaceutical Teachers of India (APTI) _x0019-5464
856			_uhttps://www.ijper.org/sites/default/files/IndJPhaEdRes-55-2-374.pdf _yClick here
942			_2ddc _cAR