000			a
999			_c15652 _d15652
003			OSt
005			20211221101836.0
008			211221b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_914896 _aSandhya, Tera
245			_aIn silico elucidation of Boesenbergia rotunda phytoconstituents against diabetes mellitus
250			_aVol.15(3), Jul-Sept
260			_aMandsaur _bB.R. Nahata Smriti Sansthan _c2021
300			_a271-277p.
520			_aIntroduction: Herbal medicine has become a well-chosen treatment to reduce the negative effects of diabetes mellitus (DM) and its serious complications due to its side effects and low cost. Material and Methods: Plants of the Zingiberaceae family, for example, Boesenbergia rotunda, Renealmia alpinia, and Zingiber zerumbet have been extensively investigated for their phytoconstituents and molecular mechanisms. This study aims to examine the price for tramadol molecular interactions that exist between the various bioactive chemicals in B. rotunda and that targeted proteins associated with type 2 DM. Molecular docking studies were done to assess the binding mode and interactions of synthesized hits at binding site of receptors. Results: Results of in silico studies showed that polyphenols and flavonoids have excellent drug-likeness properties, pharmacokinetic profile against DM targets such as peroxisome proliferator-activated receptor gamma (PPARG), dipeptidyl peptidase 4 (DPP4), and α-glucosidase. Molecular docking results highlighted five of top 10 interactions correspond to pinocembrin, alpinetin, and pinostrobin with DPP4, α-glucosidase, and PPARG; pinocembrin and silybin with PPARG. These proteins involved in regulating the functions such as inflammation, insulin resistance, oxidative stress, glucose, and lipid metabolism. Conclusion: This work provides a cheapest tramadol dynamic state of B. rotunda, especially flavonoids that show their diabetic benefits.
650		0	_94639 _aPHARMACEUTICS
700			_914897 _aThakur, Santh Rani
773	0		_tInternational journal of green pharmacy _dMandsaur B.R. Nahata Smriti Sansthan
856			_uhttp://greenpharmacy.info/index.php/ijgp/article/view/3155 _yFull Text
942			_2ddc _cAR