000			a
999			_c15662 _d15662
003			OSt
005			20211221111518.0
008			211221b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_914912 _a Malviya, Vedanshu
245			_aPreparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole
250			_aVol.55(1), Jan-Mar
260			_aKarnataka _bAssociation of Pharmaceutical Teachers of India (APTI) _c2021
300			_a86-94p.
520			_aPurpose: The main objective of present study is to evaluate the effect of various factors which have direct influence on the characteristic parameters of emulsomes formulation, so that optimized combination of factors can be find out which meet the high level of set desirability criteria. The present work is focused on the optimization of emulsomes formulation by applying Box-Behnken design (BBD) of experiment. Emulsomes are the modified form of emulsomes which consists of solid lipid core surrounded by phospholipid bilayer. Methods: Emulsomes were prepared by lipid film hydration method using Phosphatidylcholine (PHL), Tristearin (TRI), Stearylamine (STR), Cholesterol (CHOL) and Bifonazole as drug candidate. Formulations were optimized by using three factor three levels Box-Behnken (BBD) design of experiment. BBD was applied considering 3 factors as independent variables viz. Phospholipid ratio to Drug (A), Phospholipid to Tristearin ratio (B) and Phospholipid ratio to Stearylamine (C) at 3 levels (-1, 0, +1) to study their effect on dependent variables viz. Particle size (Y1), Zeta Potential (Y2) and Entrapment efficiency (Y3). Results of independent variables (A, B, C) were analysed to construct quadratic equation and 3-D response surface curves for each dependent variable (Y1, Y2, Y3). Results: The optimized formulation was selected on the basis of desirability criteria of minimum particle size, maximum zeta potential and maximum entrapment efficiency. The final optimized formulation has predicted particle size (390.394 nm), zeta potential (45.0mV) and entrapment efficiency (81.642%). Conclusion: BBD is remarkable design of experiment for studying the effect of 3-factors at 3-levels on the responses in optimizing the emulsomes formulation.
650		0	_94639 _aPHARMACEUTICS
773	0		_dBengluru Association of Pharmaceutical Teachers of India (APTI) _x0019-5464 _tIndian journal of pharmaceutical education and research
856			_uhttps://www.ijper.org/sites/default/files/IndJPhaEdRes_55_1_86.pdf _yClick here
942			_2ddc _cAR