000			a
999			_c15669 _d15669
003			OSt
005			20211221121258.0
008			211221b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_914927 _aSreeharsha, Nagaraja
245			_aDoxorubicin Hydrochloride Loaded Polyanhydride Nanoformulations and Cytotoxicity
250			_aVol.55(1), Jan-Mar
260			_aKarnataka _bAssociation of Pharmaceutical Teachers of India (APTI) _c2021
300			_a117-125p.
520			_aThis study aimed to evaluate DOX∙HCl loaded P(DLLA-CO:60:40) nanoformulations with a copolymer of F127 as a potential drug delivery system for cancer. DOX ∙ HCl was encapsulated in nanoformulations of Poly DL-lactic acid co castor oil 60:40, P(DLLACO: 60:40) polymer with the copolymer/stabilizer Pluronic® F127. The mean diameter of the cylindrical rod shape of the nanoformulation particles was 248±2.4-260±3.2 nm with an acceptable poly dispersibility of 0.29- 0.33 and a smooth surface as visualized by DSC, SEM and XRD displayed that DOX∙HCl was present as an disordered crystalline or amorphous state in the nanoformulations. The nanoformulations showed a steady pattern of drug discharge for 24 hrs. F-3 and F-4 formulations had IC50 values of 3.2±0.03 and 1.98±0.08 mcg/ml while the free drug inhibition concentration of IC50 was 2.2 mcg/ml. The drug-loaded nanoformulations showed significant cytotoxic effects on MCF-7 breast cancer cell lines.
650		0	_94639 _aPHARMACEUTICS
700			_914928 _aHiremath, Jagadeesh G.
773	0		_x0019-5464 _tIndian journal of pharmaceutical education and research _dBengluru Association of Pharmaceutical Teachers of India (APTI)
856			_uhttps://www.ijper.org/sites/default/files/IndJPhaEdRes_55_1_117.pdf _yClick here
942			_2ddc _cAR