000			a
999			_c15687 _d15687
003			OSt
005			20211222120603.0
008			211222b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_914960 _aAsmaa Mohamed Abdel-Aziz
245			_aTribulus terrestris Saponins Improve Ovarian Ischemia-reperfusion Injury in Female Rats: Modulation of Vascular Endothelial Growth Factor-A and Hemeoxygenase-1
250			_aVol.54(1), Jan-Mar
260			_aKarnataka _bAssociation of Pharmaceutical Teachers of India (APTI) _c2021
300			_a240-248p.
520			_aAim/Background: Ovarian I/R is a popular gynecological emergency, complicating ovarian torsion. TTS, reported to have many therapeutic effects along with being an antioxidant, anti- inflammatory and anti-apoptotic agent. The aim of this study was to estimate the probable protective role of Tribulus terrestris Saponin (TTS) in recovering the damaging effects of ischemia-reperfusion (I/R) in the female rats' ovarian tissue. Materials and Methods: TTS was treated to female rats in presence or absence of ovarian I/R. Results: I/R caused ovarian damage, represented by deformity in normal ovarian histological structure, with a significant oxidative and nitrosative stress along with obvious inflammatory damage. Pretreatment with TTS significantly reversed the I/R induced ovarian toxic effects. TTS may have valuable ovarian protective effects against ovarian I/R injury. Conclusion: TTS protection is given via antioxidant, anti-nitrosative, anti-inflammatory and anti-apoptotic mechanisms with advancement of vascular angiogenesis and pituitary-gonadal axis up regulation.
650		0	_94639 _aPHARMACEUTICS
700			_914962 _aHanaa Hassanein Mohammed
773	0		_tIndian journal of pharmaceutical education and research _dBengluru Association of Pharmaceutical Teachers of India (APTI) _x0019-5464
856			_uhttps://www.ijper.org/sites/default/files/IndJPhaEdRes_55_1_240.pdf _yClick here
942			_2ddc _cAR