000			a
999			_c15693 _d15693
003			OSt
005			20211222131151.0
008			211222b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_914972 _aKarumanchi, Srikanth Kumar
245			_aDesign, Synthesis, Hypoglycemic Activity and Molecular Docking Studies of 3-substituted-5- [(furan-2-yl)-methylene]-thiazolidine-2,4-dione Derivatives
250			_aVol.55(1), Jan-Mar
260			_aKarnataka _bAssociation of Pharmaceutical Teachers of India (APTI) _c2021
300			_a266-275p.
520			_aBackground: From the wide range of previous literature studies indicated that thiazolidinedione’s reacts with substituted benzaldehydes undergoes knoevenagel condensation gives respective arylidene derivatives. In our attempt all the titled compounds were designed and developed by replacement of substituted benzaldehydes with furan- 2-aldehyde, so that furan moiety was introduced in the molecule. Materials and Methods: 5-[(furan-2-yl)-methylene]-thiazolidine-2,4-dione was prepared via knoevenagel condensation by the reaction of thiazolidine-2,4-dione and furfural. Further it was coupled with various alkyl/ aryl halides in alcoholic potassium hydroxide to produce various derivatives 2a-2j. The titled compounds furthermore prepared by microwave assisted synthesis technique. Synthesized compounds were analysed by physical and spectral characterization methods. Developed furan bearing thiazolidine-2,4-diones were evaluated for in-vivo hypoglycemic property. Molecular docking analysis was carried out to observe the binding interaction of designed ligands at PPARγ target receptor protein. Results and Conclusion: Microwave irradiation technique produced high yield at less reaction time in comparison with traditional conventional method. In-vivo hypoglycemic activity evaluation revealed that, electron releasing groups (-OH and –OCH3) containing compounds 2d and 2g found to possess significant activity in acute study as well as in chronic study. Even the molecular docking studies at PPARγ receptor protein (PDB ID- 2PRG), electron releasing groups containing compounds 2d and 2g exhibit significant binding affinity having high binding energy of -9.02 kcal/mol and -8.61 kcal/mol when compared with standard ligand rosiglitazone.
650		0	_94639 _aPHARMACEUTICS
700			_914973 _a Rao, Atmakuri Lakshmana
773	0		_dBengluru Association of Pharmaceutical Teachers of India (APTI) _x0019-5464 _tIndian journal of pharmaceutical education and research
856			_uhttps://www.ijper.org/sites/default/files/IndJPhaEdRes_55_1_266.pdf _yClick here
942			_2ddc _cAR