| 000 | a | ||
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| 999 |
_c15722 _d15722 |
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| 003 | OSt | ||
| 005 | 20220107113149.0 | ||
| 008 | 211223b xxu||||| |||| 00| 0 eng d | ||
| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
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| 100 |
_915026 _aTHAKOR, JINAL M. |
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| 245 | _aPrediction of functional, structural and stability changes in pmm2 gene associated with nephrotic syndrome using computational analysis | ||
| 250 | _aVol.13(7) | ||
| 260 |
_aM P _bInnovare Academic Sciences Pvt Ltd _c2021 |
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| 300 | _a87-93P. | ||
| 520 | _aObjective:Nephrotic syndrome defines as a disorder with a group of symptoms like proteinuria, hypoalbuminemia, hyperlipidemia, and edema.PMM2encodes phosphomannosemutase protein enzyme involved in the synthesis of N-glycan.Methods:Different Insilico analysis tools: SIFT, PolyPhen, PROVEAN, SNPandGO, MetaSNP, PhDSNP, MutPred, I-Mutant, STRUM, PROCHECK-Ramachandran, COACH and ConSurf, were used to check the effect of nsSNP on protein structure and function.Results: The genetic polymorphism in thePMM2gene was retrieved from NCBI ClinVar and UniProtKB. Total20 SNPs were predicted most significant and responsible for disease-causing and decrease protein stability.Conclusion:Keywords:nsSNP, PMM2, Nephrotic syndrome, Insilico analysisThis study helps to discover disease-causing deleterious SNPs with different computational tools and gives information about potent SNPs. | ||
| 650 | 0 |
_94639 _aPHARMACEUTICS |
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| 700 |
_97153 _a Mistry, Kinnari N. |
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| 773 | 0 |
_dBhopal Innovare Academic Sciences Pvt Ltd _tInternational journal of pharmacy and pharmaceutical science _x2656-0097 |
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| 856 |
_uhttps://innovareacademics.in/journals/index.php/ijpps/article/view/41802/24989 _yClick here |
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| 942 |
_2ddc _cAR |
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