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_c15724 _d15724 |
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| 003 | OSt | ||
| 005 | 20220107113435.0 | ||
| 008 | 211223b xxu||||| |||| 00| 0 eng d | ||
| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
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| 100 |
_915028 _a ARUMUGAM, KAUSLYA |
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| 245 | _aFormulation and evaluation of floating microspheres of ciprofloxacin by solvent evaporation method using different polymers | ||
| 250 | _aVol.13(7) | ||
| 260 |
_aM P _bInnovare Academic Sciences Pvt Ltd _c2021 |
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| 300 | _a101-108p. | ||
| 520 | _aObjective: The main intention of this research was to formulate and evaluate floating microspheres of ciprofloxacin using different polymers to prolong gastric residence time. Methods: The microspheres were formulated by the solvent evaporation method using different ratios of polymers like carbopol 940, ethylcellulose, and Hydroxy Propyl Methyl Cellulose K4M. Further, the floating microspheres were evaluated for micromeritic properties like bulk density, tapped density, angle of repose, etc., percentage yield, particle size, entrapment efficiency, floating capacity, in vitro drug release study, release kinetics, drug content, swelling index, and Fourier Transform Infrared Spectroscopy (FTIR) (Compatibility studies).Results: The ciprofloxacin microspheres showed the good flowing property. The particle size ranged from 258.1±2.21 μm to 278±2.86 μm and entrapment efficiency ranged from 63.17±0.43% to 89.90±1.32%. The IR spectrum revealed that there was no interaction between the drug and polymer. F7 formulation was found to be the best formulation. Drug release was found to be 90.70±0.89% i.e. in a controlled manner at the end of 10 h. Conclusion:The floating microspheres were prepared successfully and the results clearly stated that prepared ciprofloxacin microspheres may be safe and effective controlled drug delivery over an extended period which can increase bioavailability, patient compliance, and decrease dosing frequency. | ||
| 650 | 0 |
_94639 _aPHARMACEUTICS |
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| 700 |
_915027 _a BORAWAKE, PAYAL D. |
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| 773 | 0 |
_x2656-0097 _tInternational journal of pharmacy and pharmaceutical science _dBhopal Innovare Academic Sciences Pvt Ltd |
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| 856 |
_uhttps://innovareacademics.in/journals/index.php/ijpps/article/view/41204/24963 _yClick here |
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_2ddc _cAR |
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