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_c15735 _d15735 |
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| 003 | OSt | ||
| 005 | 20211224101208.0 | ||
| 008 | 211224b xxu||||| |||| 00| 0 eng d | ||
| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
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| 100 |
_915048 _a PRAMANIK, S. |
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| 245 | _aDevelopment of pH-Responsive Interpenetrating Polymer Networks of Polyacrylamide-g-Gum Arabica and Sodium Alginate for Gastroprotective Delivery of Gabapentin | ||
| 250 | _aVol.83(3), May-June | ||
| 260 |
_aMumbai _bIndian Journal of Pharmaceutical Science _c2021 |
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| 300 | _a473-482p. | ||
| 520 | _aIn the present work, a grafted polymer of polyacrylamide with gum arabica was synthesized as Gum acacia-g-polyacrylamide using microwave-assisted synthesis with ceric ammonium nitrate as a reaction initiator. The polymer was utilized in combination with sodium alginate to prepare interpenetrating polymer network hydrogel beads to effectively deliver gabapentin in gastrointestinal tract. The formulated interpenetrating polymer network microbeads showed pH-responsive release in a different medium. The interpenetrating polymer network hydrogel beads were processed for different analytical characterization like Fourier transform infrared spectroscopy, differential scanning calorimetry, X-ray powder diffraction and scanning electron microscopy. The Fourier transform infrared spectroscopy study confirms the formation of gum acacia-g-polyacrylamide whereas differential scanning calorimetry, X-ray powder diffraction studies confirm the appearance of gabapentin in the interpenetrating polymer network micro- bead formulations. The release of the drug from the interpenetrating polymer network structured hydrogel beads was found higher in pH 6.8 as compared to pH 1.2 and pH 7.4 indicating the effective delivery of gabapentin from the interpenetrating polymer network beads to upper duodenum for better absorption. | ||
| 650 | 0 |
_94639 _aPHARMACEUTICS |
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| 700 |
_915049 _aDUTTA, J. |
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| 773 | 0 |
_tIndian journal of pharmaceutical sciences _dNew Delhi |
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| 856 |
_uhttps://www.ijpsonline.com/articles/development-of-phresponsive-interpenetrating-polymer-networks-of-polyacrylamideggum-arabica-and-sodium-alginate-for-gast.pdf _yClick here |
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_2ddc _cAR |
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