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040 _aAIKTC-KRRC
_cAIKTC-KRRC
100 _915050
_aANJALI RAJ
245 _aBrain Training Improves Cigarette Smoke Induced Dementia in Female C57 Black 6 Mice
250 _aVol.83(3), May-June
260 _aMumbai
_bIndian Journal of Pharmaceutical Science
_c2021
300 _a483-493p.
520 _aAlzheimer’s disease is a chronic neurodegenerative disease among the elderly population. Various genetic, environmental and lifestyle factors have been associated with the etiology of Alzheimer’s disease. Cigarette smoke has been reported to be a major predisposing factor for Alzheimer’s disease and contributes to disease development. Conversely, studies have reported beneficial effects of brain training on the disease condition. The purpose of this study was to evaluate the effect of a brain training task in cigarette smoke induced dementia. Three groups of female C57 black 6 mice were used in the study with two of the groups subjected to cigarette smoke exposure. The third group was subjected to a novel object test immediately after the exposure. Brain training improved the cognitive domains of the smoke exposed mice. Brain training could also regain the neurotransmitter imbalances induced by cigarette smoke, importantly, decreased the glutamate levels in the hippocampus. Brain training also significantly decreased the hippocampal amyloid precursor protein expression levels by reducing the reactive oxygen species production. Additionally, the improved hippocampal neuronal count, post training supported the findings. The results indicated that brain training significantly decreased the deleterious effects of cigarette smoke in hippocampus tissue and improved dementia symptoms
650 0 _94639
_aPHARMACEUTICS
700 _915051
_a MADHUNAPATULA, S. V.
773 0 _tIndian journal of pharmaceutical sciences
_dNew Delhi
856 _uhttps://www.ijpsonline.com/articles/brain-training-improves-cigarette-smoke-induced-dementia-in-female-c57-black-6-mice.pdf
_yClick here
942 _2ddc
_cAR