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040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_915057 _a BUKKAPATNAM, V.
245			_aExperimental Design Methodology for Simultaneous Determination of Anti-Diabetic Drugs by Reverse Phase Liquid Chromatographic Method
250			_aVol.83(3), May-June
260			_aMumbai _bIndian Journal of Pharmaceutical Science _c2021
300			_a523-534p.
520			_aA liquid chromatographic method has been established for the separation of metformin, glipizide, gliclazide, glibenclamide and glimepiride using experimental design. The main intention of this method is to optimize suitable chromatographic conditions for the proper elution of the drug molecules with minimal analysis time. The relationship between the individual and combined effect of critical process parameters and chromatographic efficiency was made clear and was achieved with the aid of experimental design methodology. Waters Sunfire C18 type column (150×4.6 mm, 5 μm particle size) was employed and 0.1 % acetic acid in water: acetonitrile mixture was adopted as mobile phase (flow rate: 0.469 ml/min) for the separation of analytes. The developed method was validated and has been extended for the assay of marketed formulations.
650		0	_94639 _aPHARMACEUTICS
700			_915058 _aMUKTHINUTHALAPATI, MATHRUSRI ANNAPURNA
773	0		_dNew Delhi _tIndian journal of pharmaceutical sciences
856			_uhttps://www.ijpsonline.com/articles/experimental-design-methodology-for-simultaneous-determination-of-antidiabetic-drugs-by-reverse-phase-liquid-chromatogra.pdf _yClick here
942			_2ddc _cAR