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999			_c15750 _d15750
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005			20220730102438.0
008			211224b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_915075 _aParavastu, Venkata Kamala Kumari
245			_aApplication of Box-Behnken Design for Formulation Parameters of Eslicarbazepine Tablets
250			_aVol.83(3), May-June
260			_aMumbai _bIndian Journal of Pharmaceutical Science _c2021
300			_a575-583p.
520			_aCurrent research has been done to develop statistically and optimized immediate release tablets for eslicarbazepine. Nineteen formulations of eslicarbazepine acetate immediate release tablets are prepared by wet granulation. The three-dimensional Box-Behnken design at three levels (33) was developed to study how selected independent variables affect dependent responses. After the initial test, three independent items were selected as follows; polyvinylpyrrolidone (A), tapioca starch (B) and galbanum gum (C). Responses to measure were the time of disintegration (Y1) and in vitro drug release at 45 min (Y2). In accordance with the independent variables, three different levels were established as the lowest, highest and middle variables tested. The predicted formula formulated with the Box-Behnken statistical design consisted of polyvinylpyrrolidone, tapioca starch and galbanum gum at the optimum levels of 2.49, 2.77 and 3 respectively.
650		0	_94639 _aPHARMACEUTICS
700			_915076 _a YARRAGUNTLA, S. R.
773	0		_dNew Delhi _tIndian journal of pharmaceutical sciences
856			_uhttps://www.ijpsonline.com/articles/application-of-boxbehnken-design-for-formulation-parameters-of-eslicarbazepine-tablets.pdf _yClick here
942			_2ddc _cAR