000			a
999			_c15759 _d15759
003			OSt
005			20211224154202.0
008			211224b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_915091 _aKWON, DA AE
245			_aStandardized Extract (HemoHIM) from Angelica gigas Nakai, Cnidium officinale Makino and Paeonia lactiflora Pallas Extract Attenuates Acetaminophen-Induced Liver Injury in Human Hepatocellular Carcinoma Cells and Mice Model
250			_aVol.83(2), March-April
260			_aMumbai _bIndian Journal of Pharmaceutical Science _c2021
300			_a195-203p.
520			_aIn this study, the hepatoprotective e ffects of the herbal preparation (HemoHIM) against acetaminophen- induced liver injury were investigated in vitro and in vivo. We investigated the messenger Ribonucleic acid expression of antioxidant factors and proinflammatory cytokines in human hepatocellular carcinoma cells treated with acetaminophen. In vivo study, Institute of Cancer Research mice was divided intofive groups (n=10): control, acetaminophen, HemoHIM 250, 500 mg/kg body weight and silymarin 200 mg/kg body weight, respectively. Mice were administrated acetaminophen (350 mg/kg body weight) on d 5 after sample administration. Blood samples were collected for aspartate aminotransferase, alanine transaminase assessment. Liver tissue was determined for glutathione, triglyceride, cholesterol and histopathological features. HemoHIM has significant effects in the treatment groups compared to acetaminophen group.
650		0	_94639 _aPHARMACEUTICS
700			_915092 _a KIM, Y. S.
773	0		_dNew Delhi _tIndian journal of pharmaceutical sciences
856			_uhttps://www.ijpsonline.com/articles/standardized-extract-hemohim-from-emangelica-gigas-nakaiem-emcnidium-officinaleem-makino-and-empaeonia-lactifloraem-pall.pdf _yClick here
942			_2ddc _cAR