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100 _915128
_a ABOALHAIJA, NOUR
245 _aIn vitro and In vivo Evaluation of the Wound Healing Potential of the Extracts of Schinus molle L. (Anacardiaceae) Grown in Jordan
250 _aVol.83(2), March-April
260 _aMumbai
_bIndian Journal of Pharmaceutical Science
_c2021
300 _a261-270p.
520 _aThe aim of this study was to assess the wound healing potential of Schinus molle L. aqueous and ethanol extracts. First, the antimicrobial activity of Schinus molle extracts was tested against six microorganisms (Staphylococcus aureus, Escherichia coli , Pseudomonas aeruginosa , Staphylococcus epidermidis , Enterococcus faecalis and Citrobacter freundii) . The growth of Citrobacter freundii and Enterococcus faecalis was totally inhibited by the aqueous extract at the lowest tested concentration (1.56 mg/ml). Next, in vitro wound healing assays were performed using humanfibroblast cells’ proliferation and scratch tests. Based on the obtained promising results, the aqueous extracts were further tested in an in vivo excision wound model in rats. Animals were treated with a hydrogel formula enriched with the plant aqueous extract in two different concentrations (2 % and 5 %). Re-epithelialization, fibrosis and neovascularization of the epidermis and sub-epidermal cells in the regenerated tissue was observed, accompanied by an increase in the tensile strength of the skin of the rats treated with the plant aqueous extract when compared to the negative control group. Our results strongly support the use of Schinus molle aqueous extracts in topical formulations to promote wound healing.
650 0 _94639
_aPHARMACEUTICS
700 _915131
_a AFIFI, FATMA
773 0 _tIndian journal of pharmaceutical sciences
_dNew Delhi
856 _uhttps://www.ijpsonline.com/articles/emin-vitroem-and-emin-vivo-em-evaluation-of-the-wound-healing-potential-of-the-extracts-of-emschinus-molleem-l-anacardia.pdf
_yClick here
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_cAR