000			a
999			_c15778 _d15778
003			OSt
005			20211228104743.0
008			211228b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_915132 _a RAGHAVENDRA, H. L.
245			_aUnderstanding Pharmacodynamics of Butyl Isobutyl Phthalate: Where In vitro and In silico Studies Converge
250			_aVol.83(2), March-April
260			_aMumbai _bIndian Journal of Pharmaceutical Science _c2021
300			_a271-277p.
520			_aRecent epidemiological studies suggest that postprandial hyperglycemia is an independent risk factor for cardiovascular disease. A human’s high carbohydrate diet majorly consists of a high carbohydrate diet and α-glucosidase is a glucosidase located in the brush border of the small intestine is involved in glycosidic cleavage of starch at α-glycosidic bonds. α-glucosidase inhibitors are a unique class of anti-diabetic drugs particularly useful in individuals with a high carbohydrate diet. α-glucosidase inhibitors works by competitively inhibiting the enzymeα-glucosidase at the brush border of the small intestines, thus delaying the digestion of complex carbohydrate and intestinal absorption of glucose. Hence, in the present study, the α-glucosidase inhibition activity of butyl isobutyl phthalate isolated from chloroform fraction ofRubus steudneri leaves investigated and its possible mechanism of action ascertained in silico . The compound was found to exhibit concentration-dependent inhibition of α-glucosidase with half-maximal inhibitory concentration value of 10.68 g/ml. The results of in vitro α-glucosidase inhibition assay for butyl isobutyl phthalate were promising and substantiated by molecular docking and molecular dynamics studies.
650		0	_94639 _aPHARMACEUTICS
700			_915133 _a BHARATH, R.
773	0		_tIndian journal of pharmaceutical sciences _dNew Delhi
856			_uhttps://www.ijpsonline.com/articles/understanding-pharmacodynamics-of-butyl-isobutyl-phthalate-where-emin-vitroem-and-emin-silicoem-studies-converge.pdf _yClick here
942			_2ddc _cAR