000			a
999			_c15792 _d15792
003			OSt
005			20211228144556.0
008			211228b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_915157 _a Mao, Xiuhua
245			_aInhibitory effect of hydroxysafflor yellow pigment a on human gastric adenocarcinoma BGC-823 xenograft in nude mice
250			_aVol.83(2), March-April
260			_aMumbai _bIndian Journal of Pharmaceutical Science _c2021
300			_a362-370p.
520			_aIn China, the incidence rate and mortality rate of gastric cancer are in the second place among all tumors and the pathological type is mainly adenocarcinoma. The higher prevalence rate requires us to do more research. It is of great signi ficance to study the antitumor e ffect of hydroxysa fflor yellow pigment A in gastric adenocarcinoma. The aim of this study was to investigate the inhibitory e ffect of hydroxysa fflor yellow pigment A on human gastric adenocarcinoma BGC-823 xenograft in nude mice. The animal model of human gastric adenocarcinoma BGC-823 was established in nude mice to carry out the experiment and then the transmission electron microscope was used to observe and analyze the experimental data. The results showed that on the 4 th d after inoculation, there were more subcutaneous tumor masses in nude mice and on the 7 th d, all the nude mice formed tumor blocks with the size of 0.4 cm to 0.8 cm and the tumorigenesis rate was 100 %. With the continuous administration, the tumor weight of the small dose group was only 0.88 g, which was much smaller than that of the model group. The average percentage of early apoptosis in low dose group was 2.48 % and that in model group was 0.44 %. In the low dose group, the volume of tumor cells became smaller and apoptotic bodies appeared. Therefore, it is of great significance to study the inhibitory effect of hydroxysafflor yellow pigment A on human gastric adenocarcinoma BGC- 823 xenograft in nude mice.
650		0	_94639 _aPHARMACEUTICS
700			_915158 _aFang, Zhen
773	0		_dNew Delhi _tIndian journal of pharmaceutical sciences
856			_uhttps://www.ijpsonline.com/articles/inhibitory-effect-of-hydroxysafflor-yellow-pigment-a-onhuman-gastric-adenocarcinoma-bgc823-xenograft-innude-mice.pdf _yClick here
942			_2ddc _cAR