000			a
999			_c15804 _d15804
003			OSt
005			20211229100533.0
008			211229b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_915177 _aJadhav, V. V.
245			_aFormulation and evaluation of mesoporous silica nanoparticle loaded fast dissolving tablet of tamoxifen
250			_aVol.83(1), Jan-Feb
260			_aMumbai _bIndian Journal of Pharmaceutical Science _c2021
300			_a32-38p.
520			_aBreast cancer is a cancer which has significant societal impact because it generally affects the young age people. Tamoxifen is Biopharmaceutical Classification System class II drug. This active pharmaceutical ingredient have problem with solubility. Most of the anti-cancerous drugs have problem with solubility because of their complicated structures. To deal with this problem mesoporous silica nanoparticles of tamoxifen are prepared. Drug entrapped in mesoporous structure which is having size less than 200 nm. It leads to improvement in solubility and further bioavailability. Various studies after formulation show improvement in solubility and decrease in particle size. Further fast dissolving tablet is prepared to improve bioavailability. Pre compression studies and post compression studies show tablet dissolve within 30 s. Hence mesoporous silica nanoparticles are best way to improve solubility
650		0	_94639 _aPHARMACEUTICS
773	0		_dNew Delhi _tIndian journal of pharmaceutical sciences
856			_uhttps://www.ijpsonline.com/articles/formulation-and-evaluation-of-mesoporous-silica-nanoparticle-loaded-fast-dissolving-tablet-of-tamoxifen.pdf _yClick here
942			_2ddc _cAR