000			a
999			_c15807 _d15807
003			OSt
005			20211229102347.0
008			211229b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_915182 _a Reddy, Kavya Handenahalli Ramakrishna
245			_aStatistical optimization and evaluation of a multi release unit bilayer tablet of rizatriptan benzoate
250			_aVol.83(1), Jan-Feb
260			_aMumbai _bIndian Journal of Pharmaceutical Science _c2021
300			_a52-59p.
520			_aMigraine, a neurological condition is often associated with intense, throbbing, crippling headaches for hours to days. Rizatriptan benzoate has established its potential in controlling the symptoms of migraine. The present study aims to formulate a bilayer tablet of rizatriptan with multi release unit matrix embedded in the sustained layer to achieve a pulsatile release of the drug to control the various phases of migraine. A preliminary study on four matrices-F1, F2, F3 and F4 with different proportion of carnauba wax and ethyl cellulose was done to evaluate the release pattern of rizatriptan in fasted state simulated intestinal fluid at pH 6.5. A simplex lattice design was used to find out the optimized ratio of the matrices to control the dissolution of rizatriptan benzoate in a predetermined fashion at different hour’s intervals. The release profile was optimized with a blend of three different formulations (F1:F2:F3=0.53:0.24:0.23). Statistical analysis revealed that the percentage error between the predicted and optimum blend was less than 5 %. The immediate release layer was formulated with direct compression method using super disintegrants. The evaluation of bilayer tablet was done for hardness, weight variation, friability, uniformity of content and percentage release. The tablet met the criteria of pharmacopoeial requirements. The bilayer tablet of rizatriptan benzoate could able to release the drug instantly as comparable with marketed immediate release tablet of rizatriptan benzoate and could also prolong the release for 24 h. The accelerated stability study also showed the tablets could retain their property at variable temperature and humidity. Therefore, it can be concluded that the bilayer tablet of rizatriptan benzoate embedded in a wax polymer multi release unit matrix has a potential to deliver the drug at a predetermined rate for the effective control of migrainee.
650		0	_94639 _aPHARMACEUTICS
700			_914759 _a Bhattacharyya, Sayani
773	0		_tIndian journal of pharmaceutical sciences _dNew Delhi
856			_uhttps://www.ijpsonline.com/articles/statistical-optimization-and-evaluation-of-a-multi-release-unit-bilayer-tablet-of-rizatriptan-benzoate.pdf _yClick here
942			_2ddc _cAR