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100			_915185 _a Li, Qi Xiong
245			_aProtective effects of valsartan on gentamicin induced tubular injury through down regulation of urinary N-acetyl-Y-D-glucosaminidase in rats
250			_aVol.83(1), Jan-Feb
260			_aMumbai _bIndian Journal of Pharmaceutical Science _c2021
300			_a69-75p.
520			_aUrinary N-acetyl- β-D-glucosaminidase is a marker of early tubular damage. Therefore, the current study was to investigate effects and its underling mechanisms of valsartan on gentamicin induced renal tubular injury through urinary N-acetyl- β-D-glucosaminidase parameter variety in rats. Animals were divided into four groups consisting of 12 rats each. The study lasted for 10 d. Rats were treated in two batches on the 6 th and 11 th d of the experiment, with 6 rats in each group. Control group rats were administered with distilled water (10 ml/kg) daily via an intragastric gavage; gentamicin group rats were given gentamicin 100 mg/kg/d intraperitoneally; valsartan (10 mg/kg/d, intragastric gavage)+gentamicin group; valsartan (20 mg/kg/d, intragastric gavage)+gentamicin group. Rats treated with gentamicin showed significant elevation in the activity and expression of urinary N-acetyl- β-D-glucosaminidase as compared with the control group; the activities of superoxide dismutase, glutathione peroxidase and catalase were lower while malondialdehyde was higher in kidney tissues; urinary protein content was not changed; serum creatinine and blood urea nitrogen were increased. Moreover, pathological damage of the renal tubules was serious in gentamicin treated rats. Valsartan significantly inhibited activity and expression of urinary N-acetyl- β-D-glucosaminidase in a dose dependent manner; dramatically increased superoxide dismutase, glutathione peroxidase and catalase activities and markedly decreased malondialdehyde levels in kidney tissues; renal tubular structural damages were also effectively ameliorated by valsartan. These results show that changes of urinary N-acetyl- β-D- glucosaminidase levels can re flect the extent of renal tubular injury, that valsartan has protective role on gentamicin-induced renal tubular injury by down-regulation urinary N-acetyl- β-D-glucosaminidase, and its down-regulation urinary N-acetyl- β-D-glucosaminidase effect may be due to its antioxidant properties in kidney tissues.
650		0	_94639 _aPHARMACEUTICS
700			_915186 _a Jiang, Xiao Ye
773	0		_dNew Delhi _tIndian journal of pharmaceutical sciences
856			_uhttps://www.ijpsonline.com/articles/protective-effects-of-valsartan-on-gentamicin-induced-tubular-injury-through-down-regulation-of-urinary-nacetylbdglucosa.pdf _yClick here
942			_2ddc _cAR