000			a
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005			20211229111623.0
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040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_915189 _aYang, Hui
245			_aPreparation and evaluation of O/W and W/O microemulsions containing diclofenac sodium
250			_aVol.83(1), Jan-Feb
260			_aMumbai _bIndian Journal of Pharmaceutical Science _c2021
300			_a84-92p.
520			_aMicroemulsions are widely used as potential drug delivery systems, especially through the dermal route as a means to avoid systemic side effects. Also, it is well known that the formation and characteristics of microemulsions depend on their composition. This study aimed to investigate the influence of various types and ratios of components which could dissolve diclofenac sodium on microemulsion formation in term of size of microemulsion regions through the construction of sixteen pseudoternary phase diagrams using the titration method. The data obtained were used to prepare oil-in-water and water-in-oil diclofenac sodium microemulsions. Two o/w and two w/o blank microemulsions were selected from the system providing the largest microemulsion region and these were subsequently incorporated with 1 % w/w diclofenac sodium. Afterward, their physicochemical and drug release properties were assessed. The largest microemulsion region was found in the system consisting of 2:1 Cremophor RH40:Span 80, ethylhexyl palmitate and 2:1 water:isopropanol. Characteristics of diclofenac sodium microemulsions were similar to those of their blank counterparts, with the exception of the drug-contained microemulsions having higher conductivity. Our findings indicated that compatibility of oil and surfactant structures was the crucial parameter for microemulsion formation. Furthermore, the present research not only expanded the phase behavior studies of microemulsions using different blends of Cremophor RH 40 and Span 80 as surfactant and cosurfactant mixtures, but also reported the application of ethylhexyl palmitate in microemulsion formulations. Incorporation of diclofenac sodium into four studied microemulsions did not affect microemulsion type. Location of the drug, drug mobility and interfacial film rigidity in microemulsions were found to influence the release characteristics of the loaded drug.
650		0	_94639 _aPHARMACEUTICS
700			_915190 _a Amnuaikit, Thanaporn
773	0		_dNew Delhi _tIndian journal of pharmaceutical sciences
856			_uhttps://www.ijpsonline.com/articles/preparation-and-evaluation-of-ow-and-wo-microemulsions-containing-diclofenac-sodium.pdf _yClick here
942			_2ddc _cAR