000			a
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005			20211229112640.0
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040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_915191 _aYanchun, Z.
245			_aProtective effect of ipomoea staphylina against cadmium-induced cardiotoxicity in wistar rats
250			_aVol.83(1), Jan-Feb
260			_aMumbai _bIndian Journal of Pharmaceutical Science _c2021
300			_a93-100p.
520			_aThe present study was aimed to evaluate the protective effect of ethanolic extract of Ipomoea staphylina leaves against cadmium-induced cardiotoxicity in rats. Rats were segregated into four groups which included normal control, cadmium treated, Cd+ Ipomoea staphylina (200 mg/kg) treated, and Cd+ Ipomoea staphylina (400 mg/kg) treated. The cadmium treatment resulted in a signi ficant increase in the activities of lactate dehydrogenase, creatine phosphokinase, serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase. Also, a signi ficant increase in the levels of cholesterol, triglycerides, and low-density lipoprotein was noticed after cadmium treatment. On the other hand, high-density lipoprotein was significantly decreased following cadmium treatment. A signi ficant decline in the activity of antioxidant enzymes was observed in cadmium intoxicated rats. Moreover, cadmium intoxicated rats resulted in signi ficant increase in the levels of proin flammatory cytokines such as tumor necrosis factor alpha, interleukin 1 beta, and nitric oxide in the cardiac tissue. Supplementation of Ipomoea staphylina leaves extract to cadmium treated rats reversed most of the indices. The extract (400 mg/kg) revealed better protective effects by decreasing the activities of lactate dehydrogenase, creatine phosphokinase, serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase and improving the lipid profile. Besides, the extract also signi ficantly improved the antioxidant enzymes activity and decreased the level of tumor necrosis factor alpha, interleukin 1 beta, and nitric oxide. Further, the histopathological study of heart supported the protective effects of Ipomoea staphylina leaves extract. The study, therefore, concludes that Ipomoea staphylina leaves extract holds a strong protective effect against cadmium-induced cardiotoxicity in rats.
650		0	_94639 _aPHARMACEUTICS
700			_915192 _aXue, Jin
773	0		_tIndian journal of pharmaceutical sciences _dNew Delhi
856			_uhttps://www.ijpsonline.com/articles/protective-effect-of-emipomoea-staphylinaem-against-cadmiuminduced-cardiotoxicity-in-wistar-rats.pdf _yClick here
942			_2ddc _cAR