000			a
999			_c15891 _d15891
003			OSt
005			20220101161557.0
008			220101b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_915330 _a Sharma, Shivani
245			_aA laconic review on liquid chromatography mass spectrometry (LC-MS) based proteomics technology in drug discovery
250			_aVol.11(3), July-Sep
260			_aRaipur _bAsian Pharma Press _c2021
300			_a194-201p.
520			_aLiquid chromatography mass spectrometry is a powerful technique which is used for the new product development, manufacturing, and to the control the stability or drug abuse. These techniques were commonly preferred in pharmacokinetics studies in pharmaceutical products. The principle involved in the LC-MS technique was justified in our study to understand the basic fundamentals of LC-MS. Also, it is used in combination with HPLC for chemical analysis. Many applications and the future prospects have been highlighted regarding the use for LC-MS in analytical chemistry. It is basically depends on the metabolites which are collected in this technique, furthermore the chemicals are analyzed according to the nature of suitability of LC-MS. This technique was helpful in the analysis of protein components identified in terms of pharmacovigilance, organic/inorganic hybrid nanoflowering. Also, our study highlights the techniques involved in proteomics. In LC-MS-based proteomics, complex mixtures of proteins are first subjected to enzymatic cleavage, then the resulting peptide products are analyzed using a mass spectrometer; this is in contrast to "top-down" proteomics, which deals with intact proteins and is limited to single protein mixtures. So, this review aims to highlight the basic introduction, and principle involved in liquid chromatography-mass spectrometry (LC-MS). Also, the advantages, or application of LC-MS were studied. Most importantly the LC-MS based proteomics, and the future aspects of LC-MS technology were studied in this review.
650		0	_94639 _aPHARMACEUTICS
700			_915331 _a Singh, Navdeep
773	0		_dRaipur Asian Pharma Press _x2231-5683 _tAsian journal of pharmaceutical research
856			_uhttps://asianjpr.com/AbstractView.aspx?PID=2021-11-3-9 _yClick here
942			_2ddc _cAR