000			a
999			_c15910 _d15910
003			OSt
005			20220106114648.0
008			220106b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_915360 _aKhan, Hamid
245			_aIdentification and characterization of degradation products of valsartan by UPLC/Q-TOF-MS technique
250			_aVol.11(1), Jan-Mar
260			_aRaipur _bAsian Pharma Press _c2021
300			_a1-5p.
520			_aUPLC/Q-TOF-MS (Ultra-performance liquid chromatographic/quadrupole time-of-flight mass spectrometric) technique has been applied for identification and characterization of degradation products of Valsartan. For identification of drugs, the Q-TOF mass spectrometer was operated in negative ionization mode and quantification was done using the MS/MS transitions at m/z 434.50 to 255.50. The chromatographic separation was achieved on Acquity UPLCTM BEH C18 (100.0 × 2.1 mm, 1.7µm) column using isocratic mobile phase consisting of acetonitrile-2mM ammonium acetate (50:50, v/v) at a flow rate of 0.25 mL/min. Drug was degraded when treated with acid, alkali and oxidative stress conditions but found stable in photolytic condition. Degradation products were identified and possible degradation mechanisms were established.
650		0	_94639 _aPHARMACEUTICS
773	0		_x2231-5683 _tAsian journal of pharmaceutical research _dRaipur Asian Pharma Press
856			_uhttps://asianjpr.com/AbstractView.aspx?PID=2021-11-1-1 _yClick here
942			_2ddc _cAR