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| 005 | 20220119115401.0 | ||
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_aAIKTC-KRRC _cAIKTC-KRRC |
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| 100 |
_915492 _aRawal, Pinkey |
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| 245 | _aEvaluation of gastroprotective effects of methanol extract of tephrosia villosa against experimentally induced ulcers in wistar rats | ||
| 250 | _aVol.13 (11) | ||
| 260 |
_aBhopal _bInnovare Academic Sciences Pvt Ltd _c2021 |
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| 300 | _a20-23p. | ||
| 520 | _aObjective: The present research work was designed to investigate the gastroprotective potentials of methanol extract of Tephrosia villosa. Methods: The aerial parts of Tephrosia villosa were dried under shade, powdered and deffated with petroleum ether and then marc leftover was subjected to methanol extraction using soxhlet apparatus using soxh-let apparatus. Antiulcer activity of methanol extract was determined against stress-induced and aspirin-induced ulcers in experimental animal models. The total number of ulcers formed, ulcer index, percentage inhibition, ulcerated area, protected area, pH and Total acidity were parameters in the study. Results: Methanol extract of Tephrosia villosa at medium (200 mg/kg) and high (200 mg/kg) could significantly (P<0.01) reduced the total number of ulcers formed, ulcer index, ulcerated area and total acidity in therapeutic groups compared to vehicle control and thereby significantly (P<0.01) increased percentage inhibition of ulcers and protected area which was evident by the significant rise in pH of gastric content. The effect of extracts was dose-dependent and results were comparable to that of standard drug omeprazole. Conclusion: The results obtained from the present work suggest that the methanol extract of Tephrosia villosa possess significant anti-ulcer potentials against experimentally induced ulcers in albino rats. | ||
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_94774 _aPHARMACOLOGY |
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| 700 |
_915493 _aRamesh C. |
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_915048 _a PRAMANIK, S. |
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| 773 | 0 |
_dBhopal Innovare Academic Sciences Pvt Ltd _tInternational journal of pharmacy and pharmaceutical science _x2656-0097 |
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| 856 |
_uhttps://innovareacademics.in/journals/index.php/ijpps/article/view/41277/25552 _yFull Article |
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_2ddc _cAR |
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