000			a
999			_c16036 _d16036
003			OSt
005			20220122144702.0
008			220122b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_915555 _a Jilani, Jamal Abdellatif
245			_aSynthesis, characterization and biological evaluation of some 2-arylbenzoxazole acetic acid derivatives as potential anticancer agents
250			_aVol.60(B), Nov
260			_aNew Delhi _bCSIR _c2021
300			_a1496-1501p.
520			_aA series of 2-arylbenzoxazole compounds possessing a cytotoxic activity as potential anticancer agents has been synthesised. Oxidative coupling of benzaldehyde with o-aminophenol utilizing lead tetraacetate approach has been used to realize the synthesis of compounds 1-11. The cytotoxicity of 1-11 have been screened against breast cancer cell line MCF-7 and human colon cancer cell line HCT-116 utilizing doxorubicin as reference drug. Among these compounds, 2-(3- benzyloxyphenyl)benzoxazole-5-acetic acid 5 and 2-(4-methoxyphenyl)benzoxazol-5-acetic acid 10, are found to be promising cytotoxic compounds against MCF-7 cell line. In addition, this study shows that the presence of acetic acid group at position 5 of benzoxazole nucleus enhances the activity. Moreover, it is noticed that the presence of oxygen atom directly linked to the phenyl substituent improves activity. The results offer a new benzoxazole based template to design and develop novel antineoplastic agents.
650		0	_95009 _aGENERAL CHEMISTRY
700			_915556 _aQais Ibrahim Abualassal
773	0		_dNew Delhi NISCAIR-CSIR 2005 _tIndian journal of chemistry (Section B)
856			_uhttp://nopr.niscair.res.in/bitstream/123456789/58509/1/IJC%20%28Section%20B%29%2c%2060B%2c%201496-1501%20%28Nov%2c2021%29.pdf _yClick here
942			_2ddc _cAR