000			a
999			_c16215 _d16215
003			OSt
005			20220204104528.0
008			220204b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_915845 _aTej, Pratap Singh
245			_aFormulation development and characterization of nanoemulsion-based gel for topical application of raloxifene hydrochloride
250			_aVol.55(4), Oct-Dec
260			_aKarnataka _bAssociation of Pharmaceutical Teachers of India (APTI) _c2021
300			_a996-1007p.
520			_aBackground: Nanoemulsion-gels are nanosized droplets, and thermodynamically stable oil-in-water dispersion. Raloxifene hydrochloride a selective estrogen receptor modulator currently its more research is being laid on in treatment of diseases in estrogen deficient postmenopausal women. Objectives: The objective of this research was to formulate nanoemulsion-gel of raloxifene for topical delivery. Materials and Methods: The oil, surfactant and cosurfactant were selected on the basis of maximal solubility of raloxifene. The screening of surfactant and cosurfactant were on the basis of their emulsification efficacy with oil to form homogenization mixture on gentle shaking. The nanoemulsions were prepared by ternary phase diagram method using different ratio of oil and surfactant-cosurfactant mixture (Smix) and nanoemulsion region obtained by excel sheet design triangular software. Results: The composition of the optimized nanoemulsion contains 0.072 %w/v raloxifene, 14.29 %v/v oil phase (Labrafil-M2125CS), 33.33%v/v Smix (Cremophor-RH40:Transcutol-P, 1:1), and 52.38%v/v distilled water. The optimized nanoemulsion was converted into gel form by addition of 1%w/v Carbopol-934. The formulation NEG2 possessed droplets size 56.73±0.58 nm, zeta-potential -22.20±0.02 mV, spreadability 18.35±0.45 gcm-1sec-1 and viscosity 98.54±0.39 mPas. The ex vivo permeation of NEG2 (22.38%) was comparatively lower to the permeation of NE3 (26.68%). Also, flux of NEG2 (11.96±0.4 μgcm-2h-1) significantly lower permeability than NE3(16.28±0.7μgcm-2h-1). But nanoemulsion-gel form is maintained more effective concentration within skin due to adhesive nature of gel form remain contact on the applied area for a long duration. Nanoemulsion-gel found stable during six months. Conclusion: The outcome of this study points out the nanoemulsiongel better than nanoemulsion because of adhesive nature and less permeability. Consequently, It maintain more raloxifene concentration at applied skin.
650		0	_94639 _aPHARMACEUTICS
700			_915846 _aFarhan Jalees Ahmad
773	0		_x0019-5464 _tIndian journal of pharmaceutical education and research _dBengluru Association of Pharmaceutical Teachers of India (APTI)
856			_uhttps://www.ijper.org/sites/default/files/IndJPhaEdRes-55-4-996.pdf _yClick here
942			_2ddc _cAR