000			a
999			_c16227 _d16227
003			OSt
005			20220204145659.0
008			220204b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_915865 _a Das, Sanjita
245			_aFormulation and evaluation of the antidiabetic, hypolipidemic and antioxidant potential of the tablets of arbortristoside-a from the seeds of nyctanthes arbortristis linn.
250			_aVol.55(4), Oct-Dec
260			_aKarnataka _bCSIR _c2021
300			_a1074-1083p.
520			_aAim: Literature shows the traditional as well as scientific proven medicinal importance of Nyctanthes arbortristis Linn. In the it was aimed at to formulate and screen the antidiabetic, hypolipidemic and antioxidant properties of the tablets of arbortristoside-A obtained from N. arbortristis seeds. Materials and Methods: Arbortristoside-A was chemically isolated from the seeds’ ethanolic extract of N. arbortristis. The antioxidant property of arbortristoside-A was screened in-vitro by the help of DPPH (2,2-diphenyl-1- picrylhydrazyl) methodology. The granules of arbortristocide-A with suitable excipients were prepared by wet granulation method. The tablets were prepared by the help of rotating punch tablet machine and subjected to standard evaluation process. Its antidiabetic property was evaluated by using streptozotocin-induced diabetic wistar rats of either sex. This study also included a serum biochemical assays and pancreatic and hepatic histopathological modification. Results: Daily oral treatment with tablets of arbortristoside-A and glibenclamide (10 mg/kg) for three weeks reduced the plasma glucose, cholesterol, triglycerides, AST and ALT levels significantly whereas improvement in HDL-cholesterol level was observed (p<0.01) as that of the diabetic control animals. Significant recovery of the pancreas and liver was observed with the tablets administration which was supported by its significant antioxidant activity. Conclusion: Present results indicated that the tablets of arbortristoside-A have prominent effect in the overall management of diabetes mainly at its higher dose (75 mg/kg) in the diabetic due to its antilipidemic and antioxidant properties.
650		0	_94639 _aPHARMACEUTICS
700			_915866 _aKhan, Irfan
773	0		_x0019-5464 _dBengluru Association of Pharmaceutical Teachers of India (APTI) _tIndian journal of pharmaceutical education and research
856			_uhttps://www.ijper.org/sites/default/files/IndJPhaEdRes-55-4-1074.pdf _yClick here
942			_2ddc _cAR