000			a
999			_c16242 _d16242
003			OSt
005			20220208093324.0
008			220208b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_915890 _aGupta, Vinay Kumar
245			_aScreening of anti-hyperglycaemic and anti- hyperlipidemic activities of leaves extracts of cassia glauca lam. on streptozotocin-nicotinamide induced NIDDM rats
250			_aVol.55(4), Oct-Dec
260			_aKarnataka _bAssociation of Pharmaceutical Teachers of India (APTI) _c2021
300			_a1115-1124p.
520			_aAim: The objective of the present study was to screen the anti-hyperglycaemic and antihyperlipidemic activities of leaf extracts (Pet-ether, Chloroform, Acetone, and Methanol) of Cassia glauca Lam. on streptozotocin-nicotinamide induced NIDDM rats. Methods: Acute oral toxicity of all extracts was carried out with a single dose of 2000 mg/kg in female non-pregnant albino Wistar rats. An oral glucose tolerance test was performed for all extracts in overnight fasted rats. The anti-hyperglycaemic and anti-hyperlipidemic activities were carried out on adult healthy albino Wistar rats of either sex. Diabetogenic drug Streptozotocin and Nicotinamide were administrated by intraperitoneal route. Standard drug glibenclamide was administered by the peroral route. Test drugs (extracts) were administered in doses of 200 mg/kg by the peroral route. Diabetic rats with serum glucose levels more than 250 mg/dl were selected for the study. Bodyweight, fasting serum glucose levels, and other biochemical parameters were monitored on the 1st, 15th, and 21st day. Results: All four-leaf extract showed significant anti-hyperglycemic and lipid-lowering activity. Maximum activity was shown by methanolic extract (effect on FSGL=282.20±5.29 on day 1st to 139. 20±3.46 on 21st day, p˂0.01), (effect on lipid parameters= (TG=105.69±0.71 on 15th day to 110.19±0.70 on 21st day, p˂0.01, CH=105.68±0.50 on 15th day to 111.37±0.48 on 21st day, p˂0.01 and S.HDL=37.29±0.22 on 15th day to 38.05±0.44 on 21st day, p˂0.01. Conclusion: From the present study a conclusion can be drawn that the methanolic extract of C. glauca leaves possesses potential anti-hyperglycaemic and anti-hyperlipidemic properties.
650		0	_94639 _aPHARMACEUTICS
700			_915891 _aPathak, Asha
773	0		_x0019-5464 _tIndian journal of pharmaceutical education and research _dBengluru Association of Pharmaceutical Teachers of India (APTI)
856			_uhttps://www.ijper.org/sites/default/files/IndJPhaEdRes-55-4-1115.pdf _yClick here
942			_2ddc _cAR