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_c16243 _d16243 |
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003 | OSt | ||
005 | 20220208093807.0 | ||
008 | 220208b xxu||||| |||| 00| 0 eng d | ||
040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
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100 |
_915892 _aDighe, Amol Sopanrao |
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245 | _aIn silico investigation and molecular docking study of triazolo-thiadiazole derivatives for antimicrobial, anti-inflammatory and anti-diabetic activity | ||
250 | _aVol.55(4), Oct-Dec | ||
260 |
_aKarnataka _bAssociation of Pharmaceutical Teachers of India (APTI) _c2021 |
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300 | _a1125-1144p. | ||
520 | _aTriazolo-thiadiazole and connected fused ring in heterocyclic compounds are of highly interest in potential bioactive molecules. Triazolo-thiadiazole derivatives have lead of organic chemists due to their good biological and chemotherapeutic significance. Research in the field of anti-mycobacterium, anti-inflammatory, anti-diabetic and anti- microbial therapies are ongoing and studies are seeking. Therefore, the discovery of new effective anti-mycobacterium, anti-inflammatory, anti-diabetic and antimicrobial agents are imperative. Swiss programs are used to predict Triazolo-thiadiazole derivatives properties that are important for drug profile. Later, all of them were docked into the active sites of enzymes namely Ribosomal RNA large subunit methyltransferase (1P91), PeriplasmicOligopeptide-Binding Protein (1B05) and Protein-tyrosine phosphatase, non-receptor type 1 (1q6s), those were considered in Antidiabetic studies of triazolo- thiazazole derivative. Docking study when compared with Triazolo-thiadiazole derivatives with standard drug, derivative docking result is better. Ciprofloxacin, ibuprofen, and acarbose have been used as standard drugs for antimicrobial, anti-inflammatory and anti- diabetic activity in comparative docking studies. | ||
650 | 0 |
_94639 _aPHARMACEUTICS |
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700 |
_915893 _aSen, Ashim Kumar |
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773 | 0 |
_dBengluru Association of Pharmaceutical Teachers of India (APTI) _x0019-5464 _tIndian journal of pharmaceutical education and research |
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856 |
_uhttps://www.ijper.org/sites/default/files/IndJPhaEdRes-55-4-1125.pdf _yClick here |
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942 |
_2ddc _cAR |