| 000 | a | ||
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| 999 |
_c16281 _d16281 |
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| 003 | OSt | ||
| 005 | 20220208154803.0 | ||
| 008 | 220208b xxu||||| |||| 00| 0 eng d | ||
| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
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| 100 |
_915960 _aSreeja, S. |
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| 245 | _aComputational molecular modelling of 2-aminobenzimidazole derivatives: strong successor of hypoglycaemic agent | ||
| 250 | _aVol.13(9) | ||
| 260 |
_aM P _bInnovare Academic Sciences Pvt Ltd _c2021 |
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| 300 | _a16-21p. | ||
| 520 | _aObjective: The present study was aimed to design different analogues of 2-aminobenzimidazole and find the binding ability by Insilico method. Methods: Various soft wares like Chemsketch, Molinspiration, PASS, and Discovery studio were used to design the proposed derivatives. Evaluation of binding activity against different receptors was detected and checked their physicochemical properties for binding.Results: In this study, we designed different analogs of 2-aminobenzimidazole into a ligand having a binding affinity with alpha-glucosidase, Dipeptidyl–peptidase 4(DPP4), Peroximase proliferator-activated receptor gamma (PPARγ), and Insulin-like growth factor 1(IGF-1) receptor. The designed ten derivatives showed a significant binding capacity to the concerned receptors. Conclusion: These results pointed that the designed proposed derivatives promising hypoglycaemic activity. | ||
| 650 | 0 |
_94639 _aPHARMACEUTICS |
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| 700 |
_915961 _aAnton Smith, A. |
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| 773 | 0 |
_x2656-0097 _tInternational journal of pharmacy and pharmaceutical science _dBhopal Innovare Academic Sciences Pvt Ltd |
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| 856 |
_uhttps://innovareacademics.in/journals/index.php/ijpps/article/view/41877/25268 _yClick here |
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| 942 |
_2ddc _cAR |
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