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_c16284 _d16284 |
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| 003 | OSt | ||
| 005 | 20220209101437.0 | ||
| 008 | 220209b xxu||||| |||| 00| 0 eng d | ||
| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
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| 100 |
_915965 _aSirin, Salma Sultana |
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| 245 | _aIn vitro antileishmanial activities of three medicinal plants: argemonemexicana, murraya koenigii and cinnamomum tamala against miltefosine resistant promastigotes of leishmania donovani parasites | ||
| 250 | _aVol.13(9) | ||
| 260 |
_aM P _bInnovare Academic Sciences Pvt Ltd _c2021 |
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| 300 | _a27-33p. | ||
| 520 | _aObjective: Leishmaniasis is one of the neglected tropical diseases in terms of drug development and discovery. Non-responsiveness and resistance to the drug in Leishmaniaspecies need to develop new antileishmanial potentials; herbal medicines could be the alternative one.Methods: In the present study, semi-purified fractions were prepared from the traditionally used three medicinal plants of India: Argemone mexicana (aerial shoot), Murraya koenigii (stem), and Cinnamomum tamala (bark) by using multiple solvent systems (non-polar to polar, beginning with petroleum ether followed by n-hexane, benzene, and chloroform) and an effort was given to assess the leishmanicidal activities against Leishmania donovani miltefosine resistant HePC-R (Ld/MIL-30) promastigotes in vitroand the IC50 concentrations were estimated.Results: The study revealed that the semi-purified fractions of A. mexicana, M. koenigii, and C.tamala have effective antileishmanial activities and the 50% inhibitory concentrations (IC50) are 50 μg/ml, 98 μg/ml, and 200 μg/ml, respectively. At these (IC50) concentrations, these plant semi-purified fractions were found to interfere in lipid and protein biosynthesis, alter cell morphology, DNA content, mitochondrial membrane potential, generating ROS, and apoptosis in promastigotes. The semi-purified fractions were also found noticeably non-toxic towards host splenocytes.Conclusion: These results could suggest that A. mexicana, M. koenigii, and C.tamala could carry potential novel compounds for the development of new drugs against Leishmaniasis. | ||
| 650 | 0 |
_94639 _aPHARMACEUTICS |
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| 773 | 0 |
_x2656-0097 _dBhopal Innovare Academic Sciences Pvt Ltd _tInternational journal of pharmacy and pharmaceutical science |
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| 856 |
_uhttps://www.innovareacademics.in/journals/index.php/ijpps/article/view/42349/25274 _yClick here |
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| 942 |
_2ddc _cAR |
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