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_c16297 _d16297 |
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| 005 | 20220209133508.0 | ||
| 008 | 220209b xxu||||| |||| 00| 0 eng d | ||
| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
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| 100 |
_915988 _aShougrakpam, Priyadarshini |
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| 245 | _aComparative study of anticonvulsant effect of the leaves of sapindus emarginatus and acorus calamus in experimentally induced animal models of epilepsy | ||
| 250 | _aVol.13(1) | ||
| 260 |
_aM P _bInnovare Academic Sciences Pvt Ltd _c2021 |
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| 300 | _a36-39p. | ||
| 520 | _aObjective:To compare anticonvulsant activity of methanol extracts of Sapindus emarginatus (MESE) and Acorus calamus (MEAC) in experimental seizure models in mice. Methods:Hind limb tonic extension (HLTE) in Maximal electroshock (MES)seizureand clonic seizure in Pentylenetetrazol (PTZ) seizure models were assessed. Group I (control) mice received 1% gum acacia in distilled water (1 ml/100 g). Topiramate (50 mg/kg) was administered in group II (standard) animals. Group III and IV mice were treated with 200 and 400 mg/kg of MESE, respectively. Mice in group V and VI were given MEAC at the dose of 200 and 400 mg/kg, respectively. Drugs were given orally suspended in 1% gum acacia suspension (1 ml/100 g) for 7 d. Next day after 1 h of drug administration, the seizure was induced for evaluation.Results: Anticonvulsant property of both extracts was confirmed by reduction (p<0.001) in HLTE phase in MES model; delayed onset of the clonic seizure (p<0.001) and its shortened phase (p<0.001) in PTZ model when compared with the control. MESE-200 mg/kg produced significantlylonger (p<0.001) HLTE phase with lower protection (40.34%) among the different doses of the extracts. Clonic seizure onsets and durations in PTZmodel were comparable among the different extract-treated groups; however, mortality was higher (66.6%) with MESE-200 mg/kg.Conclusion: Anticonvulsant activity of MESE and MEAC was evident; however, MESE at the dose of 200 mg/kg was less effective. | ||
| 650 | 0 |
_94639 _aPHARMACEUTICS |
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| 700 |
_915989 _aBhattacharjee, Abhishek |
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| 773 | 0 |
_x2656-0097 _dBhopal Innovare Academic Sciences Pvt Ltd _tInternational journal of pharmacy and pharmaceutical science |
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| 856 |
_uhttps://innovareacademics.in/journals/index.php/ijpps/article/view/39872/24085 _yClick here |
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| 942 |
_2ddc _cAR |
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