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| 005 | 20220210095133.0 | ||
| 008 | 220210b xxu||||| |||| 00| 0 eng d | ||
| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
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| 100 |
_916011 _aArun, K. |
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| 245 | _aEvaluation of antidiabetic activity of zanthoxylum ovalifolium leaf extracts | ||
| 250 | _aVol.13(2) | ||
| 260 |
_aM P _bInnovare Academic Sciences Pvt Ltd _c2021 |
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| 300 | _a56-60p. | ||
| 520 | _aObjective:The present study was aimed to investigate the antidiabetic activity of ethanolic and aqueous extract of Zanthoxylum ovalifoliumon alloxan induced diabetic rat model in rats.Methods: The leaves of Zanthoxylum ovalifoliumwere evaluated for antidiabetic activity by using alloxan induced diabetic model in diabetic rats. Diabetes was induced by single intraperitoneal injection of alloxan (100 mg/kg) and rats were treated orally with test extracts, standard drug (glibenclamide 5 mg/kg) and vehicle for 21 d. The hypoglycemic effects and lipid profile of diabetic rats were assessed using diagnostic kits. Finally, histopathological studies were carried out for pancreas.Results: The acute toxicity studies revealed at the dose of 2000 mg/kg (b. w) of Zanthoxylum ovalifolium for ethanol and aqueous extract were found to be safe. A significant reduction (p<0.001) in blood glucose was observed in diabetic rats treated with different doses of extracts compared to untreated diabetic rats. The drug possesses a good hyperlipidemic effect by normalizing the lipid parameters. This was evidenced by histopathological studies; both glibenclamide and 400 mg/kg of Ethanolic extract does appear to be regulated diabetes at the cellular level, resulting in the restoration of near normal architecture pancreatic islet of langerhans.Conclusion:It can be concluded from our research findings that ethanolic and aqueous extract of Zanthoxylum ovalifoliumat high dose (400 mg/kg) exhibited significant antihyperglycemic activity than extract at low dose (200 mg/kg) in alloxan induced diabetic rats. These extracts also showed improvement in parameters like lipid profile as well as regeneration β-cells in the pancreas and so might be of value in diabetes treatment. | ||
| 650 | 0 |
_94639 _aPHARMACEUTICS |
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_916012 _aVirupaksha, J. H. |
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| 773 | 0 |
_dBhopal Innovare Academic Sciences Pvt Ltd _tInternational journal of pharmacy and pharmaceutical science _x2656-0097 |
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| 856 |
_uhttps://innovareacademics.in/journals/index.php/ijpps/article/view/37636/24297 _yClick here |
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_2ddc _cAR |
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