000			a
999			_c16336 _d16336
003			OSt
005			20220211095050.0
008			220211b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_916054 _aMathew, CICI
245			_aDesign, synthesis and antimicrobial studies of 5-benzylidene substituted rhodanine containing heterocycles
250			_aVol.13(5)
260			_aM P _bInnovare Academic Sciences Pvt Ltd _c2021
300			_a28-34p.
520			_aObjective: The principal objective of the study was to synthesize and evaluate the biological activities of a novel class of 5-benzylidene substituted rhodanine derivatives as antimicrobial agents.Methods: All the synthesized compounds (D1-D10) were screened for their antimicrobial activities using microdilution methods as per the reported procedure.All compounds were evaluated as potential antimicrobial agents against gram-positive bacteria: Bacillus cereus, Staphylococcus aureus, gram negative bacteria: Escherichia coli Pseudomonas aeruginosa and Klebsiella pneumoniae Fungal cultures used in the study were Aspergillus niger, Candida albicans, Candida parapsilosis, Candida tropicalis and Candida glabrata.Results: Compound D6 showed good antifungal activity in the MIC range 16μg/mlagainst Candida tropicalisand Compound D10 showed good antifungal activity in the MIC range 16μg/mlagainst Candida glabrata. Compounds D2 and D5 showed good antibacterial activity at 32μg/ml. all the other compounds showed moderate antibacterial activity. Conclusion: Based on the above results, it can be concluded that the compounds may leadto the development of more potent antimicrobial drug candidates in the near future.
650		0	_94639 _aPHARMACEUTICS
700			_916056 _aSaraswati, Bindu
773	0		_dBhopal Innovare Academic Sciences Pvt Ltd _x2656-0097 _tInternational journal of pharmacy and pharmaceutical science
856			_uhttps://innovareacademics.in/journals/index.php/ijpps/article/view/40106/24708 _yClick here
942			_2ddc _cAR