000			a
999			_c16344 _d16344
003			OSt
005			20220211111718.0
008			220211b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_916069 _aKarpakavalli, Meenakshisundaram
245			_aExtraction, isolation of active principles, anti-bacterial and wound healing activity ofthe marine algal species oedogonium globosum and oedogonium intermedium
250			_aVol.13(5)
260			_aM P _bInnovare Academic Sciences Pvt Ltd _c2021
300			_a72-77p.
520			_aObjective:Algae is the undisputed treasures of the sea and are a valuable raw material, providing unlimited opportunities for new drug discoveries. Marine algal products are in demand in the international market in the form of standardized algal extracts or semi-finished products. Methods:Aqueous and methanolic extracts of Oedogonium globosum and Oedogonium intermedium species were obtained maceration and hot percolation. The active principles from O. intermedium were isolated, purified by column chromatography, and characterized by spectral studies IR, λmax, 1HNMR and MS. Theextracts of Oedogonium species were screened for their anti-microbial effects, aResults:Comparing to Oedogonium intermedium (45 %, 90 %, 87 %), very low extractive yields were obtained for Oedogonium globosum (10.80 %, 37 %, 28 %). At phytochemical screening, Terpenoids, Flavanoids and, Glycans were found to be present in a significant amount and upon their isolation, it was found that a collection of fractions from cold extract with Rf value in the range 0.32-0.34 as Glycans and those from the hot extract with 0.40-0.72 as Flavanoids and those from methanolic extracts with 0.23, 0.44 and 0.71 as for Terpenoids. Anti-bacterial study revealed out the fact of Oedogonium species could give higher inhibition to gram-positive than for gram-negative bacteria at (10 μg/10μl/disc) concentration. No symptoms of systemic toxicity and mortality were observed. Silver sulfadiazine, more potent in wound closure, the effect of methanolic extracts of O. intermedium (87 %) was almost at par to the standard (95 %) in action and significantly greater than O. globosum (72 %, P<0.05). cute dermal irritation and wound-healing activity studies. Conclusion:Admittedly, Oedogonium type algal species can be known as medicinal algae with a plethora of a wide range of pharmacological activities. Thus, this research work may be considered further for extensive innovative discoveries of new lead molecules and any other pharmacological activities, in the future.
650		0	_94639 _aPHARMACEUTICS
700			_916070 _aPrakash Govindaraj
773	0		_tInternational journal of pharmacy and pharmaceutical science _dBhopal Innovare Academic Sciences Pvt Ltd _x2656-0097
856			_uhttps://innovareacademics.in/journals/index.php/ijpps/article/view/40026/24706 _yClick here
942			_2ddc _cAR