000			a
999			_c16840 _d16840
003			OSt
005			20220623141414.0
008			220623b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_916741 _aKale, Pravin Popatrao
245			_aCopper-lowering agents as an adjuvant in chemotherapy
250			_aVol.53(3), May-June
260			_aMumbai _bWolter Kluwer _c2021
300			_a221-225p.
520			_aCopper is an important element essential for metabolism and normal human body function. Although it is an essential element, related imbalance leads to toxic effects. Studies have proved that there is an increase in copper level in cancer cells. Evidences suggest the link between increase in copper levels and progression of various types of cancers. Different strategies have been utilized to decrease the level of copper in various types of cancer cells. However, it was observed that cell machinery involved in copper homeostasis plays critical factor in lowering copper levels in cancer cells. The outcomes of many monotherapies consisting copper-lowering agents for the treatment of different types of cancers showed that the inhibition of single factor is not sufficient to inhibit the growth of cancer cells. The combination of copper-lowering agent with chemotherapeutic agent showed synergistic effect. Interestingly, the presence of copper-lowering agent in such combinations significantly improved the efficacy of chemotherapeutic agent. The present work has focused on the discussion of outcomes of studies involving anti-copper agent and chemotherapeutic agent and related future strategies.
650		0	_94774 _aPHARMACOLOGY
700			_916742 _aKadu, Pramod
773	0		_tIndian Journal of Pharmacology _dAndheri - Mumbai Wolters Kluwer India Private Limited _x0253-7613
856			_uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262414/ _yClick here
942			_2ddc _cAR