000			a
999			_c16862 _d16862
003			OSt
005			20220623160443.0
008			220623b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_916763 _aAditya, Ashish
245			_aRopivacaine induced systemic toxicity in a patient with phacomatosis pigmentokeratotica
250			_aVol.53(2), Mar-Apr
260			_aMumbai _bWolter Kluwer _c2021
300			_a153-156p.
520			_aCalculation of the maximum recommended dose of local anesthetic minimizes the risk of Local Anesthetic Systemic Toxicity (LAST) when administrating multiple blocks for lower limb surgeries. Ropivacaine is the preferred local anesthetic as it is less lipophilic than bupivacaine and thus results in less central nervous system (CNS) and cardiovascular toxicity. The presence of developmental, congenital, and metabolic disorders mandates an extracautious approach in the administration of large volume of Local anaesthesia (LA) as the vascularity of the limb, levels of alpha-1-acid glycoprotein, and sensitivity of the sodium channels may be altered. This case report highlights successful resuscitation of a patient with Phacomatosis pigmentokeratotica after the development of CNS toxicity secondary to the administration of ropivacaine in ultrasound-guided combined lumbar plexus and sciatic nerve block. We identified some high risk patient profiles which should be vigilantly monitored to minimize the incidence of LAST.
650		0	_94774 _aPHARMACOLOGY
700			_916764 _aParitosh, Amar
773	0		_tIndian Journal of Pharmacology _x0253-7613 _dAndheri - Mumbai Wolters Kluwer India Private Limited
856			_uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265418/ _yClick here
942			_2ddc _cAR