000			a
999			_c16880 _d16880
003			OSt
005			20220624103106.0
008			220624b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_916778 _aBansal, Seema
245			_aConstruction of time‑response curve for neuronal and vascular endothelial dysfunction in ovariectomized rats
250			_aVol.53(1), Jan-Feb
260			_aMumbai _bWolter Kluwer _c2021
300			_a31-38p.
520			_aBACKGROUND: Studies have shown that there is a critical time period to start hormone therapy after the loss of ovarian function during menopause. The length of estrogen deprivation may evolve different pathophysiological manifestations. OBJECTIVE: The aim of the present study was to investigate behavioral, biochemical, and molecular alterations at different time points after surgical menopause with an aim and identify various pathophysiological targets to exploit “window of opportunity” and to design newer therapeutic modalities for menopause‑associated neurobehavioral and vascular deficits. MATERIALS AND METHODS: Bilateral ovariectomy was performed to induce surgical menopause and estrogen deficiency state. Menopause‑associated neuronal and vascular dysfunctions were noted after 1, 2, and 3 months of the study. RESULTS: Neuronal and vascular endothelial dysfunction post ovariectomy revealed that behavioral, biochemical, molecular, and vascular endothelial dysfunction appeared after 1 month of ovariectomy except hyperglycemia, which occurs after 3 months. CONCLUSIONS: Time‑response studies measuring behavioral, biochemical, and molecular markers at various time points after ovariectomy reveal that there is a fast onset of neuronal and vascular complications, but the duration of insulin resistance is a relatively late phenomenon.
650		0	_94774 _aPHARMACOLOGY
700			_916779 _aChopra, Kanwaljit
773	0		_tIndian Journal of Pharmacology _x0253-7613 _dAndheri - Mumbai Wolters Kluwer India Private Limited
856			_uhttps://www.ijp-online.com/temp/IndianJPharmacol53131-1732562_044845.pdf _yClick here
942			_2ddc _cAR