| 000 | a | ||
|---|---|---|---|
| 999 |
_c16971 _d16971 |
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| 003 | OSt | ||
| 005 | 20220629155136.0 | ||
| 008 | 220629b xxu||||| |||| 00| 0 eng d | ||
| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
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| 100 |
_916911 _aDerfla, A. P. |
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| 245 | _aCODESTM drug delivery: design and evaluation of metronidazole tablets | ||
| 250 | _aVol.15(4), Oct-Dec | ||
| 260 |
_aM P _bBRNSS Publication Hub. _c2021 |
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| 300 | _a400-405p. | ||
| 520 | _aAim: The present study aimed to develop and demonstrate the study of combined effects of biodegradable polymer coated with different pH-sensitive polymers in the formulation of Metronidazole tablets for colon targeted drug delivery. Materials and Methods: Metronidazole Hydrochloride is cored with various proportions of biodegradable polymers such as xanthan gum and chitosan. Then, the double-layered system was designed based on pH-sensitive eudragit S100 and eudragit L100 as an inner layer and outer layer, respectively. To evaluate the in-vitro dissolution profile of CODESTM tablets in gastrointestinal fluids, the test was performed using three consecutive media and drug release kinetics are performed. The drug excipient interaction of CODESTM formulation was characterized by Fourier transform infrared (FT-IR). Results and Discussion: From the in-vitro drug release studies, F6 tablets were considered as the optimized formulation, which retard the drug release in the stomach (pH 1.2) and small intestine (pH 7.4) and progressively increase the release of 75.75% in the colon (pH 6.8) due to mucoadhesive properties of chitosan. The FT-IR analysis shows that there is no interaction between drug and excipient. The drug release kinetics followed supercase – II transport with erosion mechanism. Conclusion: Briefly to conclude that CODESTM technology is a promising method for approach to deliver drug to colon due to the controlled release of biodegradable polysaccharides and gastric resistance polymer. | ||
| 650 | 0 |
_94755 _aPHARMACOGNOSY |
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| 700 |
_916904 _aSubramanian, S. |
||
| 773 | 0 |
_tInternational journal of green pharmacy _dMandsaur B.R. Nahata Smriti Sansthan |
|
| 856 |
_uhttps://www.greenpharmacy.info/index.php/ijgp/article/view/3187 _yClick here |
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| 942 |
_2ddc _cAR |
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