| 000 | a | ||
|---|---|---|---|
| 999 |
_c17236 _d17236 |
||
| 003 | OSt | ||
| 005 | 20220730143935.0 | ||
| 008 | 220730b xxu||||| |||| 00| 0 eng d | ||
| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
||
| 100 |
_917412 _aRajakumari, V. |
||
| 245 |
_aDevelopment and characterization of oral fast-dissolving strip incorporated with olmesartan medoxomil nanocrystals for solubility enhancement _b: Multilevel categoric optimization using DOE |
||
| 250 | _aVol.16(2), Apr-Jun | ||
| 260 |
_aMandsaur _bBRNSS Publication Hub. _c2022 |
||
| 300 | _a172-182p. | ||
| 520 | _aAim: Olmesartan medoxomil (OLM) is an antihypertensive drug available as an oral solid dosage form (tablet) with a restricted bioavailability of 28.6%. This might be attributed due to the low solubility and low permeability of the drug. The primary goal of this study was to enhance the solubility of OLM by formulating OLM nanocrystals (NC) and incorporating them into Oral Fast-Dissolving Strips (OFDSs) that will be made available for geriatric patients. Materials and Methods: Initially, nanosuspension (solvent-anti-solvent addition) was prepared using different concentrations of stabilizers and characterized for particle size (PS), polydispersity index (PDI), and zeta potential. Further, the nanosuspension was freeze-dried to obtain NC and it was characterized for crystallinity and surface morphology. In addition, the OLM NCs were incorporated into OFDS (solvent evaporation technique) and optimized by Multilevel Categoric design (24 × 2 2) using Design Expert® software. The OFDS was evaluated for weight variation, thickness, tensile strength, drug content, disintegration time, and dissolution. Results and Discussion: F30 shows PS, PDI, and zeta potential of 764.6 nm, 0.310, and −28.7 mV, respectively. The DSC thermograms showed that the reduction in crystallinity of OLM NC compared to pure OLM and the SEM images reveal rod-shaped crystals. The weight variation, thickness, surface pH, and drug content of OLM loaded OFDS obtained satisfactory results. The disintegration time, folding endurance, and tensile strength of the optimized formulation were found to be 20 ± 0.41 s, 125 ± 0.47 times, and 1328.8 ± 0.82 N/m, respectively. The drug release from the formulation was found to be 85.28% at the end of 5 min; the drug release kinetics indicated that it follows non-fickian diffusion and stability studies (25°C/60% RH) reveal that the formulation was stable. Conclusion: The results conclude that NCs approach is a promising techniques to improve solubility of poorly soluble drug. Key words: Design of experiment, nanocrystals, olmesartan medoxomil, oral fast-dissolving strip, solvent evaporation, solvent-antisolvent addition | ||
| 650 | 0 |
_94639 _aPHARMACEUTICS |
|
| 700 |
_917400 _aNithya, R. |
||
| 773 | 0 |
_tInternational journal of green pharmacy _dMandsaur B.R. Nahata Smriti Sansthan _x0973-8258 |
|
| 856 | _uhttps://www.greenpharmacy.info/index.php/ijgp/article/view/3251 | ||
| 942 |
_2ddc _cAR |
||