000			a
999			_c17345 _d17345
003			OSt
005			20220826151727.0
008			220826b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_917628 _aSabi, Essa M.
245			_aProtective effects of ficus benghalensis in streptozotocin (STZ) induced diabetic zebrafish (Danio rerio) model
250			_aVol.56(3), Jul-Sep
260			_aKarnataka _bAssociation of Pharmaceutical Teachers of India (APTI) _c2022
300			_a822-829p.
520			_aBackground: Diabetes Mellitus (DM) is a chronic metabolic disorder that is characterized by hyperglycemia. Severe complications such as cardiovascular disease, neuropathy, nephropathy, and retinopathy are associated with DM. Objectives: To explore a safer treatment option with no/less adverse effects, we evaluated the potential of Ficus benghalensis to alleviate certain diabetic conditions. Materials and Methods: Administering streptozotocin to zebrafish intraperitoneally induced diabetes. After induction, Ficus benghalensis hydroethanolic bark extract was administered to zebrafish in different concentrations (5, 10, and 15 μg/mL). Biochemical blood parameters such as Blood Glucose, total cholesterol levels, triglycerides, and liver enzymes such as alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase were analyzed. Results: Treating the streptozotocin-induced group with Ficus benghalensis hydroethanolic bark had a hypoglycemic effect and reduced the cholesterol, triglycerides, and liver enzymes. The histopathological evaluation also showed improvement in the damaged pancreatic tissues. Conclusion: Our results suggest that Ficus benghalensis hydroethanolic bark extract can be used as a potent therapeutic candidate for treating diabetes.
650		0	_94639 _aPHARMACEUTICS
700			_917629 _aMujamammi, Ahmed H.
773	0		_x0019-5464 _dBengluru Association of Pharmaceutical Teachers of India (APTI) _tIndian journal of pharmaceutical education and research
856			_uhttps://www.ijper.org/sites/default/files/IndJPhaEdRes-56-3-822.pdf _yClick here
942			_2ddc _cAR