000			a
999			_c18365 _d18365
003			OSt
005			20221128165035.0
008			221128b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_919273 _aBasavaraj, H.
245			_aExperimental design approach for validation and optimisation of spectrophotometric determination of cefixime in pharmaceutical dosage form
250			_aVol.84(1), Jan-Feb
260			_aMumbai _bIndian Journal of Pharmaceutical Science _c2022
300			_a115-120p.
520			_aTwo simple, sensitive and precise spectrophotometric methods for the assay of cefixime in either pure form or in its pharmaceutical dosage form are described. The method I is based on the reaction of salicylaldehyde with cefixime resulting in a yellow coloured product, absorbs at λmax 425 nm. The second method describes the reaction between the diazotized drug and N-(1-naphthyl)ethylenediamine dihydrochloride to yield a purple coloured product with λmax at 567 nm. The reaction conditions were optimized to get maximum colour intensity. The absorbance was found to extend linearly with increasing the concentration of cefixime the systems obeyed the Beer’s law within the range of 2-10 μg/ml and 5-25 μg/ml for salicylaldehyde and N-(1-naphthyl)ethylenediamine dihydrochloride methods. Common excipients used as additives in pharmaceutical dosage don’t interfere within the proposed analytical methods. The products are stable for over 6 h and 10 h respectively. The proposed methods are simple, sensitive, accurate and suitable for quality control uses.
650		0	_94639 _aPHARMACEUTICS
700			_919274 _aMruthyunjayaswamy, B. H. M.
773	0		_dNew Delhi _tIndian journal of pharmaceutical sciences
856			_uhttps://www.ijpsonline.com/articles/an-experimental-design-approach-for-validation-and-optimisation-of-spectrophotometric-determination-of-cefixime-in-pharm.pdf _yClick here
942			_2ddc _cAR