000			a
999			_c18421 _d18421
003			OSt
005			20221206144702.0
008			221206b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_918813 _aArvind Kumar
245			_aRecent advances in curcumin: An integrative overview of its mode of action, pharmacological properties, and health benefits
250			_aVol.16(3), Jul-Sep
260			_aMandsaur _bBRNSS Publication Hub. _c2022
300			_a226-235p.
520			_aTurmeric (Curcuma longa) is used as a spice, preservative, and coloring matter and has a wide range of medicinal and pharmacological applications. Curcumin, a polyphenolic herbal product, well-known shows healing hobby for some of the diseases, attributed specially to its chemical shape and specific physical, chemical, and organic properties. The oxidative damage and inflammation have been pointed out as the root cause of many chronic diseases such as cancer, diabetes, hypertension, and Alzheimer’s disease. Curcumin and its analogs prevent oxidative damage and inhibit the binding of toxic metabolites to DNA. The safety studies indicate that turmeric is well tolerated at a very high dose (0.5–1.5 g/day/person) without any toxic effects. Epidemiological and clinical studies of curcumin suggested that cancer could be prevented or significantly reduced by treatment with anti- oxidant and anti-inflammatory drugs, therefore, Curcumin, an anti-oxidant and anti-inflammatory compound found in turmeric (a curry spice), could be a promising option for the prevention and/or treatment of cancer and other chronic diseases. Curcumin, a highly pleiotropic drug with a great safety profile and strong molecular evidence targeting various diseases, could not attain its optimal therapeutic effect in previous clinical studies, owing to its limited solubility and poor absorption. Curcumin can be developed as a medicinal medication by enhancing its absorption and cellular uptake through better formulation qualities or delivery mechanisms. This review focuses on the properties, chemistry, toxicity studies, dosage, and the possibilities of the therapeutic application of curcumin for the prevention and/or treatment of several diseases, and their safety profile.
650		0	_94639 _aPHARMACEUTICS
700			_919346 _aChandel, Saket Singh
773	0		_dMandsaur B.R. Nahata Smriti Sansthan _x0973-8258 _tInternational journal of green pharmacy
856			_uhttps://www.greenpharmacy.info/index.php/ijgp/article/view/3298/1239 _yClick here
942			_2ddc _cAR