| 000 | a | ||
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| 999 |
_c18424 _d18424 |
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| 003 | OSt | ||
| 005 | 20221207115315.0 | ||
| 008 | 221207b xxu||||| |||| 00| 0 eng d | ||
| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
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| 100 |
_919351 _aMaharjan, Manima |
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| 245 | _aEnhanced antibacterial effect by antibiotic-loaded nanoparticles: A new strategy for battling bacterial resistance against Neisseria gonorrhoeae | ||
| 250 | _aVol.16(3), Jul-Sep | ||
| 260 |
_aMandsaur _bBRNSS Publication Hub. _c2022 |
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| 300 | _a251-261p. | ||
| 520 | _aIntroduction: The recent reoccurrence of gonorrhea in the developed countries has been followed by rise and spread of gonococcal resistance to fluoroquinolones. The current research is aimed to prolong the contact time of antibiotics to the surface of the micro-organisms through the formulation of antibiotic-loaded nanoparticles. Methods: Ionotropic gelation method was used for the preparation of ciprofloxacin-loaded chitosan nanoparticles. The effect of various factors, including concentration of chitosan, sodium tripolyphosphate (TPP) on the different parameters such as entrapment efficiency, loading efficiency, and drug release was studied. Surface morphology, particle size, and antimicrobial studies, that is, zone of inhibition and minimum inhibitory concentration were also assessed. Results: The particles prepared under optimal condition of 1.77% Chitosan and 0.2% Sodium TPP had 96.23nm with polydispersivity index 1. In these particles with 1:1.5 Ciprofloxacin hydrochloride to chitosan, the entrapment efficiency, and loading efficiency were found to be 74.59% and 78.95%, respectively, with in vitro drug release of 10.23% in 24 h. Conclusion: The developed ciprofloxacin hydrochloride-loaded chitosan nanoparticles were found to exhibit effective antimicrobial activity against Neisseria gonorrhoeae, which showed high resistance toward conventional dosage forms. | ||
| 650 | 0 |
_94639 _aPHARMACEUTICS |
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| 700 |
_911945 _aBaby, Beny |
||
| 773 | 0 |
_tInternational journal of green pharmacy _x0973-8258 _dMandsaur B.R. Nahata Smriti Sansthan |
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| 856 |
_uhttps://www.greenpharmacy.info/index.php/ijgp/article/view/3301/1243 _yClick here |
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| 942 |
_2ddc _cAR |
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