000			a
999			_c18716 _d18716
003			OSt
005			20230125111006.0
008			230125b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_919768 _aBhardwaj, Ankit
245			_aXylometazoline induced isolated left medial cerebellar peduncle infarct: a rare case report
250			_aVol.13(1), Mar
260			_aNew Delhi _bSAGE _c2022
300			_a102-107p.
520			_aXylometazoline, a sympathomimetic available as over the counter drug, acts as a nasal decongestant and has been reported as an independent risk factor for hemorrhagic and ischemic stroke. The chronic use of xylometazoline leads to either increased release of more potent vasoconstrictor norepinephrine in the presynaptic region, or acts directly on central adrenoreceptors which leads to dysfunction resulting in chronic progressive vasculopathy that manifests as an ischemic stroke. Sympathomimetics also activate 12-lipoxygenase pathways which induce proliferation and migration of vascular smooth muscle cells. 12-lipoxgenase also plays a significant role in regulating the degree and stability of platelet activation, as its activation significantly strengthens platelet activation and uncontrolled platelet activation, which may lead to myocardial infraction and stroke. The present case reports a rare case of young adult suffering from isolated left medial cerebellar peduncle infarct related to the chronic use of xylometazoline. Acute cerebellar stroke is rare, especially in young adults and represent only 3% of total ischemic and hemorrhagic strokes. Clinical symptoms, patient age at the onset of stroke, and lesion size had no significant effect on the clinical outcome. Symptoms are frequently underestimated and misdiagnosed which further lead to serious complications and poor functional outcomes.
650		0	_94774 _aPHARMACOLOGY
700			_919769 _aMukherjee, Shoma
773	0		_dNew Delhi SAGE Publications _tJournal of pharmacology and pharmacotherapeutics _x0976-500X
856			_uhttps://journals.sagepub.com/doi/full/10.1177/0976500X221080224#con1 _yClick here
942			_2ddc _cAR