000			a
999			_c18795 _d18795
003			OSt
005			20230204110145.0
008			230204b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_919876 _aChandrakala, V.
245			_aCubosomes: a boon for cosmeceuticals and topical drug delivery
250			_aVol.14(11)
260			_aM P _bInnovare Academic Sciences Pvt Ltd _c2022
300			_a13-17p.
520			_aCubosomes are the nanoparticles of bicontinuous, lyotropic cubic phases, comprised of curved lipid bilayers organized into a three-dimensional honeycomb (cavernous) like structures separating two internal aqueous channels and large interfacial area. Cubic phases are optically isotropic, very viscous, and solid-like (crystalline) with cubic crystallographic symmetry. They can encapsulate hydrophilic, hydrophobic and amphiphilic drug substances, which are able to target and control the release of the bioactive agent. The cosmetic industry has made progress in the development of products to overcome skin as a barrier and deliver the actives through the skin effectively. Drug incorporated cubosomes shows some unique advantageous like, protection from chemical and physiological degradation, in vivo drug release in a controlled manner and improving the bioavailability of drug while reducing the side effect. Cubosomes are pharmacologically inactive, non-irritant, non-toxic, effective, and cosmetically acceptable. Topical drug delivery can deliver drugs selectively to the specific site; this avoids fluctuations of drug levels and improves patient compliance and suitable local and systemic therapeutic effects. Cubosomal topical drug formulation shows outstanding potential advantages for their controlled and sustained drug delivery. This review article mainly focuses on cosmetic and topical applications of cubosomes.
650		0	_94639 _aPHARMACEUTICS
773	0		_dBhopal Innovare Academic Sciences Pvt Ltd _tInternational journal of pharmacy and pharmaceutical science _x2656-0097
856			_uhttps://innovareacademics.in/journals/index.php/ijpps/article/view/45550/27133 _yClick here
942			_2ddc _cAR