000			a
999			_c18799 _d18799
003			OSt
005			20230204145039.0
008			230204b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_919883 _aValishetti, Manoj Kumar
245			_aTo evaluate the safety and efficacy of amlodipine and chlorthalidone in combination with telmisartan in hypertensive patients attending tertiary care centre, Telangana
250			_aVol.14(11)
260			_aM P _bInnovare Academic Sciences Pvt Ltd _c2022
300			_a37-42p.
520			_aObjective:The main objective of this study is to evaluate and compare the effects of both treatments on systolic and diastolic blood pressure in 4th, and 8th weeks with baselineMethods:A prospective, comparative, Open-label, and parallel-group clinical study was conducted in out patient's department of general medicine at Osmania general hospital. 120 patients were randomly allocated into 2 groups. Group 1 with 60 patients received Tab: Telmisartan 40 mg+Amlodipine 5 mg once daily, and Group 2 with 60 patients received Tab: Telmisartan 40 mg+ Chlorthalidone 6.25 mg once daily for a period of 8 w. Follow-up was done in the 4th week and 8th week to evaluate the safety and efficacy in hypertensive patients.Results: The differences in the SBP, DBP, and HR in group A (P value<0.001) and group B (P value<0.001) at the 4th week and 8th week follow-up periods with baseline value (0 w) were statistically significant as P value<0.05.Conclusion: The combination of telmisartan plus amlodipine is equally effective as the combination of telmisartan plus chlorthalidone in decreasing SBP, DBP, HR, and MAP. No major adverse drug reactions were noted during the study period.
650		0	_94639 _aPHARMACEUTICS
700			_919884 _aYasarapu, Madhu
773	0		_x2656-0097 _dBhopal Innovare Academic Sciences Pvt Ltd _tInternational journal of pharmacy and pharmaceutical science
856			_uhttps://innovareacademics.in/journals/index.php/ijpps/article/view/46070/27138 _yClick here
942			_2ddc _cAR