| 000 | a | ||
|---|---|---|---|
| 999 |
_c18801 _d18801 |
||
| 003 | OSt | ||
| 005 | 20230204150409.0 | ||
| 008 | 230204b xxu||||| |||| 00| 0 eng d | ||
| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
||
| 100 |
_919887 _aAnila, L. |
||
| 245 | _aIn vitroantiplatelet activity of an isoflavanone isolated from methanolic extract of emblica officinalis fruits | ||
| 250 | _aVol.14(11) | ||
| 260 |
_aM P _bInnovare Academic Sciences Pvt Ltd _c2022 |
||
| 300 | _a48-53p. | ||
| 520 | _aObjective: In this study, we aimed to isolate a polyphenolic compound from a polyphenolic-rich fraction from Emblica officinalis fruits and also study its effect on adenosine diphosphate (ADP) and collagen-induced in vitro platelet aggregation.Methods: The polyphenolic-rich fraction was prepared by 80% methanolic extraction. The residue was extracted successively with hexane, benzene, ethyl acetate and n-butanol. Ethyl acetate residue was selected for column chromatography because of its high polyphenolic content. It was subjected to repeated column chromatography of series with different eluents of increasing polarity. A brown amorphous powder was obtained from ethyl acetate: methanol (7:3) fraction. This sample was subjected to UV-visible spectrum, IR spectrum, 1H NMR, 13C NMR and electrospray mass spectrum (ES-MS) studies for its structural elucidation.Results: A compound, 5, 7, 4'-trihydroxy 3'-methoxy isoflavanone was identified from polyphenolic rich ethyl acetate: methanol (7:3) fraction separated from the 80% methanolic extract of Embica officinalis fruits by repeated column chromatography. Yield of the compound was 421.05 mg/kg. This compound exhibited antiplatelet activity well comparable with that of quercetin.Conclusion: The present study proved thatthe isolated compound5, 7, 4'-trihydroxy 3'-methoxy isoflavanone exerts a significant inhibitory activityon ADP and collagen-induced in vitro platelet aggregation, which can be considered as an effective remedy for alleviating complications of cardiovascular diseases. | ||
| 650 | 0 |
_94639 _aPHARMACEUTICS |
|
| 700 |
_919888 _aHashim, M. S. |
||
| 773 | 0 |
_tInternational journal of pharmacy and pharmaceutical science _x2656-0097 _dBhopal Innovare Academic Sciences Pvt Ltd |
|
| 856 |
_uhttps://innovareacademics.in/journals/index.php/ijpps/article/view/46212/27140 _yClick here |
||
| 942 |
_2ddc _cAR |
||