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_c18808 _d18808 |
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| 005 | 20230206101143.0 | ||
| 008 | 230206b xxu||||| |||| 00| 0 eng d | ||
| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
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| 100 |
_919897 _aPooja Gurav |
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| 245 | _aBioanalytical method for estimation of teriflunomide in human plasma | ||
| 250 | _aVol.14(9) | ||
| 260 |
_aM P _bInnovare Academic Sciences Pvt Ltd _c2022 |
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| 300 | _a19-23p. | ||
| 520 | _aObjective: Teriflunomide is used for the treatment of multiple sclerosis and is available in 7 mg and 14 mg tablets. This study aimed to develop and validate a simple and economical HPTLC method for the estimation of Teriflunomide in human plasma.Methods: HPTLC method was developed using toluene: ethyl acetate: acetic acid as the mobile phase and the stationary phase was a TLC plate precoated with silica gel 60 F254. The detection wavelength set was 294 nm. The sample preparation involved a simple protein precipitation technique with Acetonitrile as a precipitating protein agent; the internal standard selected was Rilpivirine. The validation was carried out as per bio-analytical method guidelines.Results: The Rf value for Teriflunomide was found to be 0.46±0.04. The linearity range was observed from 10-60 μg/ml with a regression coefficient value of 0.9819. The developed method was validated for various parameters like specificity, linearity, accuracy, precision, recovery, and stability.Conclusion: The developed method is simple, specific, accurate, and economical for the estimation of Teriflunomide in human plasma. | ||
| 650 | 0 |
_94639 _aPHARMACEUTICS |
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| 700 |
_919898 _aDamle, Mrinalini |
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| 773 | 0 |
_tInternational journal of pharmacy and pharmaceutical science _x2656-0097 _dBhopal Innovare Academic Sciences Pvt Ltd |
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| 856 |
_uhttps://innovareacademics.in/journals/index.php/ijpps/article/view/45151/26866 _yClick here |
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| 942 |
_2ddc _cAR |
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