000			a
999			_c18809 _d18809
003			OSt
005			20230206101550.0
008			230206b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_919899 _aPragati Kumar
245			_aPhytochemical screening and in vitro antimicrobial and antifungal activity of bergenia ligulata (wall.) leaves extracts
250			_aVol.14(9)
260			_aM P _bInnovare Academic Sciences Pvt Ltd _c2022
300			_a24-29p.
520			_aObjective: Evaluation of Antimicrobial and Antifungal potential of Phytoconstituents present in leaf extracts of Bergenia ligulata (wall.)plant.Methods: The antimicrobial effects of leaves of Bergenia ligulata (wall.) were evaluated using both ethanol and aqueous extracts againstEscherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, and Penicillium spp. Agar well diffusion method was employed in determining the antimicrobial activity and the broth dilution method for determining the Minimum Inhibitory Concentration. All the isolates examined were susceptible to both the ethanol, aqueous, and the combined aqueous and ethanol extracts (synergetic effect) of the Bergenia ligulata leaves.Results: The zone of inhibition ranged from 6.93±0.02b mm to 12.81±0.03a mm, with Escherichia coli being the most susceptible at 12.81±0.03a mm to the ethanol and 11.53±0.02a mm to the aqueous extracts at 250 mg/ml concentration while P. aeruginosa and Penicillin spp. were the slightestsusceptible at 10.88±0.02a mm to the ethanol and 09.76±0.02a mm to the aqueous extract at 250 mg/ml concentration. The control/standard antimicrobial agent (Gentamicin and Metronidazole) exhibited higher inhibitory activity than the plant extracts.The least inhibitory value of 6.25 mg/ml was produced against P. aeruginosaby theethanolic extractand againstC. albicans by thecombined (aqueous and ethanol) extracts of the plant. The qualitative and quantitative phytochemical screening of the leaves of Bergenia ligulata reveals the presence of flavonoids, tannins, saponins, alkaloids, and steroids. The most abundant percentage composition observed was flavonoids (7.72%), while tannins had the least component (4.29%).Conclusion: The findings from this study show that the leaves extracts hold considerable antimicrobial activity against commonly encountered microorganisms in the environment. This, therefore, implies that it can be used as a chemotherapeutic agent which will contribute to the development of antibiotic drugs against the test organisms.
650		0	_94639 _aPHARMACEUTICS
700			_911055 _aWal, Pranay
773	0		_dBhopal Innovare Academic Sciences Pvt Ltd _x2656-0097 _tInternational journal of pharmacy and pharmaceutical science
856			_uhttps://innovareacademics.in/journals/index.php/ijpps/article/view/45345/26867 _yClick here
942			_2ddc _cAR